Polyvinyl alcohol/chitosan quaternary ammonium salt composite hydrogel with directional macroporous structure for photothermal synergistic antibacterial and wound healing promotion

After skin tissue trauma, wound infections caused by bacteria posed a great threat to skin repair. However, resistance to antibiotics, the current treatment of choice for bacterial infections, greatly affected the efficiency of anti-infection and wound healing. Therefore, there has been a critical n...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-05, Vol.267, p.131549-131549, Article 131549
Main Authors: Lan, Xianyu, Yang, Hang, Xiong, Yuzhu, Zeng, Guanyue, Dong, Fuping
Format: Article
Language:English
Subjects:
ammonium salts
antibacterial properties
Bidirectional freezing method
biocompatibility
chitosan
Directional macroporous structure
dopamine
Escherichia coli
graphene oxide
hydrogels
Photothermal synergistic antibacterial
polyethylene glycol
polyvinyl alcohol
porous media
quaternary ammonium compounds
separation
solubility
synergism
therapeutics
Wound healing
zeolites
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Summary:After skin tissue trauma, wound infections caused by bacteria posed a great threat to skin repair. However, resistance to antibiotics, the current treatment of choice for bacterial infections, greatly affected the efficiency of anti-infection and wound healing. Therefore, there has been a critical need for the development of novel antimicrobial materials and advanced therapeutic methods to aid in skin repair. In this paper, rGO-PDA@ZIF-8 nanofillers were prepared by coating graphene oxide (GO) with dopamine (DA), followed by in situ growth of zeolite imidazolate framework-8 (ZIF-8). Using polyvinyl alcohol (PVA) and chitosan quaternary ammonium salt (CS) as matrix materials, along with polyethylene glycol (PEG) as a pore-forming agent, and rGO-PDA@ZIF-8 as an antimicrobial nano-filler, we successfully prepared rGO-PDA@ZIF-8/PVA/CS composite hydrogels with a directional macroporous structure using bidirectional freezing method and phase separation technique. This hydrogel exhibited excellent mechanical properties, good solubility and water retention capabilities. In addition, the hydrogel demonstrated excellent biocompatibility. Most notably, it not only exhibited excellent bactericidal effect against E. coli and S. aureus (99.1 % and 99.0 %, respectively) under the synergistic effect of intrinsic antibacterial activity and photothermal antibacterial, but also exhibited the ability to promote wound healing, making it a promising candidate for wound healing applications.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2024.131549