Continuous Glucose Monitoring for Prediabetes: What Are the Best Metrics?

• Published in: Journal of diabetes science and technology 2024-07, Vol.18 (4), p.835-846
• Main Authors: Zahalka, Salwa J., Galindo, Rodolfo J., Shah, Viral N., Low Wang, Cecilia C.
• Format: Article
• Language: English
• Subjects: Blood Glucose - analysis; Blood Glucose Self-Monitoring; Continuous Glucose Monitoring; Humans; Prediabetic State - blood; Prediabetic State - diagnosis
• ISSN: 1932-2968; 1932-3107
• DOI: 10.1177/19322968241242487

Background: Continuous glucose monitoring (CGM) has transformed the care of type 1 and type 2 diabetes, and there is potential for CGM to also become influential in prediabetes identification and management. However, to date, we do not have any consensus guidelines or high-quality evidence to guide CGM goals and metrics for use in prediabetes. Methods: We searched PubMed for all English-language articles on CGM use in nonpregnant adults with prediabetes published by November 1, 2023. We excluded any articles that included subjects with type 1 diabetes or who were known to be at risk for type 1 diabetes due to positive islet autoantibodies. Results: Based on the limited data available, we suggest possible CGM metrics to be used for individuals with prediabetes. We also explore the role that glycemic variability (GV) plays in the transition from normoglycemia to prediabetes. Conclusions: Glycemic variability indices beyond the standard deviation and coefficient of variation are emerging as prominent identifiers of early dysglycemia. One GV index in particular, the mean amplitude of glycemic excursion (MAGE), may play a key future role in CGM metrics for prediabetes and is highlighted in this review.