Radiation‐induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report

Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation‐induced cSC...

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Bibliographic Details
Published in:Journal of dermatology 2024-11, Vol.51 (11), p.1500-1503
Main Authors: Takahashi‐Watanabe, Manami, Fujimura, Taku, Amagai, Ryo, Ohuchi, Kentaro, Yamazaki, Emi, Tamabuchi, Erika, Kuroki, Shigeru, Kambayashi, Yumi, Hashimoto, Akira, Asano, Yoshihide
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal, Humanized - adverse effects
Antibodies, Monoclonal, Humanized - therapeutic use
Antineoplastic Agents, Immunological - adverse effects
Antineoplastic Agents, Immunological - therapeutic use
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Case reports
Dermatitis
Humans
Immunosuppression
Immunotherapy
Metastases
Monoclonal antibodies
Mycosis
Mycosis fungoides
Mycosis Fungoides - diagnosis
Mycosis Fungoides - drug therapy
Mycosis Fungoides - pathology
Neoplasms, Radiation-Induced - diagnosis
Neoplasms, Radiation-Induced - drug therapy
Neoplasms, Radiation-Induced - etiology
Neoplasms, Radiation-Induced - pathology
Pembrolizumab
radiation‐induced cSCC
Risk factors
Skin - pathology
Skin - radiation effects
Skin Neoplasms - diagnosis
Skin Neoplasms - drug therapy
Skin Neoplasms - etiology
Skin Neoplasms - pathology
Squamous cell carcinoma
Targeted cancer therapy
Treatment Outcome
Citations: Items that this one cites
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Summary:Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation‐induced cSCC with a high level of tumor‐mutation burden that developed in a patient with MF who was successfully treated with pembrolizumab. The present case suggests that pembrolizumab might be an optimal therapy for radiation‐induced cSCC, even at advanced stages.
ISSN:0385-2407
1346-8138
1346-8138
DOI:10.1111/1346-8138.17221