A Comprehensive Review of Patented Antimicrobial Peptides from Amphibian Anurans

• Published in: Journal of natural products (Washington, D.C.) D.C.), 2024-03, Vol.87 (3), p.600-616
• Main Authors: García, Fabiola Almeida, Fuentes, Talia Frómeta, Alonso, Isel Pascual, Bosch, Roberto Alonso, Brunetti, Andrés E., Lopes, Norberto Peporine
• Format: Article
• Language: English
• Subjects: amino acids; amphibians; antimicrobial peptides; Anura; Asia; biodiversity conservation; drug development; Neotropics; North America
• ISSN: 0163-3864; 1520-6025; 1520-6025
• DOI: 10.1021/acs.jnatprod.3c01040

Since the 1980s, studies of antimicrobial peptides (AMPs) derived from anuran skin secretions have unveiled remarkable structural diversity and a wide range of activities. This study explores the potential of these peptides for drug development by examining granted patents, amino acid modifications related to patented peptides, and recent amphibians’ taxonomic updates influencing AMP names. A total of 188 granted patents related to different anuran peptides were found, with Asia and North America being the predominant regions, contributing 65.4% and 15.4%, respectively. Conversely, although the Neotropical region is the world’s most diversified region for amphibians, it holds only 3.7% of the identified patents. The antimicrobial activities of the peptides are claimed in 118 of these 188 patents. Additionally, for 160 of these peptides, 66 patents were registered for the natural sequence, 69 for both natural and derivative sequences, and 20 exclusively for sequence derivatives. Notably, common modifications include alterations in the side chains of amino acids and modifications to the peptides’ N- and C-termini. This review underscores the biomedical potential of anuran-derived AMPs, emphasizing the need to bridge the gap between AMP description and practical drug development while highlighting the urgency of biodiversity conservation to facilitate biomedical discoveries.