Bilayer wound dressing composed of asymmetric polycaprolactone membrane and chitosan-carrageenan hydrogel incorporating storax balsam

A comprehensive approach is needed to develop multifunctional wound dressing that is simple yet efficient. In this work, Liquidambar orientalis Mill. storax loaded hydroxyethyl chitosan (HECS)-carrageenan (kC) based hydrogel (HECS-kC) and polydopamine coated asymmetric polycaprolactone membrane (PCL...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-01, Vol.254 (Pt 3), p.128020-128020, Article 128020
Main Authors: Nakipoglu, Mustafa, Özkabadayı, Yasin, Karahan, Siyami, Tezcaner, Ayşen
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
antioxidant activity
Balsams
Bandages
Carrageenan
Chitosan
dissolved oxygen
hydrogels
Hydrogels - pharmacology
Liquidambar orientalis
permeability
Rats
separation
Sheep
tensile strength
water vapor
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Summary:A comprehensive approach is needed to develop multifunctional wound dressing that is simple yet efficient. In this work, Liquidambar orientalis Mill. storax loaded hydroxyethyl chitosan (HECS)-carrageenan (kC) based hydrogel (HECS-kC) and polydopamine coated asymmetric polycaprolactone membrane (PCL-DOP) were used to develop a multifunctional and modular bilayer wound dressing. Asymmetric PCL-DOP membrane was prepared by non-solvent induced phase separation (NIPS) followed by polydopamine coating and demonstrated an excellent barrier against bacteria while allowing permeability for 5.45 ppm dissolved‑oxygen and 2130 g/m water vapor transmission in 24 h in addition to 805 kPa tensile strength. Storax loaded HECS-kC hydrogel, on the other hand, demonstrated a pH-responsive degradation and swelling to provide necessary conditions to facilitate wound healing. The hydrogels showed stretchability above 140 %, mild adhesive strength on sheep skin and PCL-DOP membrane, while the storax incorporation enhanced antibacterial and antioxidant activity. Furthermore, rat full-thickness skin defect model showed that the developed bilayer wound dressing could significantly facilitate wound healing compared to Tegaderm™ and control groups. This study shows that the bilayered wound dressing has the potential to be used as a simple and effective wound care system.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.128020