A MUFA/carotenoid-rich oil ameliorated insulin resistance by improving inflammation and oxidative stress in obese rats

Obesity is associated with low-grade inflammation and oxidative stress, leading to insulin resistance and type II diabetes. Caryocar brasiliense pulp oil (pequi oil - PO) is rich in oleic acid and carotenoids and positively implicated in regulating inflammation and oxidative stress. This study invest...

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Published in:Molecular and cellular endocrinology 2024-02, Vol.581, p.112110-112110, Article 112110
Main Authors: Moreno, Lauane Gomes, César, Nayara Rayane, Melo, Dirceu Sousa, Figueiró, Maria Thereza Otoni, Dos Santos, Edivânia Cordeiro, Evangelista-Silva, Paulo Henrique, de Sousa Santos, Carina, Costa, Karine Beatriz, Rocha-Vieira, Etel, Dias-Peixoto, Marco Fabrício, Castro Magalhães, Flávio de, Esteves, Elizabethe Adriana
Format: Article
Language:English
Subjects:
adipose tissue
Animals
antioxidant activity
antioxidants
Antioxidants - metabolism
Antioxidants - pharmacology
biomarkers
carotenoids
Carotenoids - metabolism
Carotenoids - pharmacology
Caryocar brasiliense
diabetes
Diabetes Mellitus, Type 2
Diet, High-Fat
endocrinology
epididymis
Inflammation
Insulin - metabolism
insulin resistance
Insulin Resistance - physiology
interleukin-10
interleukin-6
lard
liver
Male
males
obesity
Obesity - drug therapy
Obesity - metabolism
oleic acid
Oxidative Stress
pulp
Rats
Rats, Wistar
seed oils
Superoxide Dismutase - metabolism
visceral fat
Western diets
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Summary:Obesity is associated with low-grade inflammation and oxidative stress, leading to insulin resistance and type II diabetes. Caryocar brasiliense pulp oil (pequi oil - PO) is rich in oleic acid and carotenoids and positively implicated in regulating inflammation and oxidative stress. This study investigated PO's antioxidant and anti-inflammatory effects in a diet-induced obesity model. Male Wistar rats were allocated into three experimental groups: Control (CD), Western Diet (WD), and Western Diet, with 27% of lard switched by PO (WDP). Metabolic, inflammatory, and oxidative stress biomarkers were evaluated after 12 weeks of diet protocols in liver and adipose tissue. WDP rats gained less body mass and epididymal fat, had less hepatic fat infiltration, and were more glucose-tolerant and insulin-sensitive than WD (p 
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2023.112110