Astrocytes ACLYmate to chronic neuroinflammation

Astrocytes are essential cells of the mammalian central nervous system (CNS), with key roles in development, homeostasis, and disease. Lee and colleagues recently showed that astrocytes can develop epigenetic memory, which enhances proinflammatory responses to subsequent stimulation, potentially dri...

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Bibliographic Details
Published in:Trends in immunology 2024-05, Vol.45 (5), p.320-321
Main Authors: Champagne-Jorgensen, Kevin, Gommerman, Jennifer
Format: Article
Language:English
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Summary:Astrocytes are essential cells of the mammalian central nervous system (CNS), with key roles in development, homeostasis, and disease. Lee and colleagues recently showed that astrocytes can develop epigenetic memory, which enhances proinflammatory responses to subsequent stimulation, potentially driving sustained neurological disease pathology, such as in multiple sclerosis (MS). Astrocytes are essential cells of the mammalian central nervous system (CNS), with key roles in development, homeostasis, and disease. Lee and colleagues recently showed that astrocytes can develop epigenetic memory, which enhances proinflammatory responses to subsequent stimulation, potentially driving sustained neurological disease pathology, such as in multiple sclerosis (MS).
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2024.04.003