Conjugated bisphenol S metabolites in human serum and whole blood

Studies have shown that bisphenol S (BPS) is mainly present as its conjugated metabolites in human blood. However, the distribution of conjugated BPS metabolites in different human blood matrices has not been characterized. In this study, paired human serum and whole blood samples (n = 79) were coll...

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Published in:Chemosphere (Oxford) 2024-06, Vol.357, p.142082-142082, Article 142082
Main Authors: Fu, Zhenling, Jin, Hangbiao, Mao, Weili, Hu, Zefu
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Language:English
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BPS-G
BPS-S
Distribution
Serum
Whole blood
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description Studies have shown that bisphenol S (BPS) is mainly present as its conjugated metabolites in human blood. However, the distribution of conjugated BPS metabolites in different human blood matrices has not been characterized. In this study, paired human serum and whole blood samples (n = 79) were collected from Chinese participants, and were measured for the occurrence of BPS and 4 BPS metabolites. BPS was detectable in 49% of human serum (
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However, the distribution of conjugated BPS metabolites in different human blood matrices has not been characterized. In this study, paired human serum and whole blood samples (n = 79) were collected from Chinese participants, and were measured for the occurrence of BPS and 4 BPS metabolites. BPS was detectable in 49% of human serum (&lt;LOD–1.7 ng/mL) and 78% of whole blood (&lt;LOD–2.1 ng/mL) samples. In both human serum and whole blood, BPS-sulfate (BPS–S; 74% and 86%, respectively) and BPS-glucuronide (BPS-G; 68% and 84%, respectively) had higher detection frequency than BPS. Consistently, BPS-S was the predominant BPS metabolite in human serum (mean 0.39 ng/mL) and whole blood (0.41 ng/mL), significantly higher than BPS-G (mean 0.13 and 0.13 ng/mL, respectively). This is contrary to the data from controlled oral exposure studies on model animals and humans, in which BPS-G was the dominant BPS metabolite in serum. 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[Display omitted] •BPS was detected in 49% of human serum and 78% of whole blood samples.•BPS-S was the predominant BPS metabolite in both human serum and whole blood.•BPS-S had a higher mean blood partitioning coefficient than BPS-G and BPS.•This study first examines partitioning of conjugated BPS metabolites in human blood.</description><identifier>ISSN: 0045-6535</identifier><identifier>EISSN: 1879-1298</identifier><identifier>DOI: 10.1016/j.chemosphere.2024.142082</identifier><identifier>PMID: 38642776</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>BPS-G ; BPS-S ; Distribution ; Serum ; Whole blood</subject><ispartof>Chemosphere (Oxford), 2024-06, Vol.357, p.142082-142082, Article 142082</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024. 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subjects BPS-G
BPS-S
Distribution
Serum
Whole blood
title Conjugated bisphenol S metabolites in human serum and whole blood
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