Therapeutic potential of gamma entrainment using sensory stimulation for cognitive symptoms associated with schizophrenia

Schizophrenia is a complex neuropsychiatric disorder with significant morbidity. Treatment options that address the spectrum of symptoms are limited, highlighting the need for innovative therapeutic approaches. Gamma Entrainment Using Sensory Stimulation (GENUS) is an emerging treatment for neuropsy...

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Bibliographic Details
Published in:Neuroscience and biobehavioral reviews 2024-06, Vol.161, p.105681, Article 105681
Main Authors: Black, Tallan, Jenkins, Bryan W., Laprairie, Robert B., Howland, John G.
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Cognitive Dysfunction - etiology
Cognitive Dysfunction - physiopathology
Cognitive Dysfunction - therapy
Gamma Rhythm - physiology
Humans
Neurocognitive
Non-pharmacological
Oscillations
Prefrontal cortex
Psychiatric
Schizophrenia - physiopathology
Schizophrenia - therapy
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Summary:Schizophrenia is a complex neuropsychiatric disorder with significant morbidity. Treatment options that address the spectrum of symptoms are limited, highlighting the need for innovative therapeutic approaches. Gamma Entrainment Using Sensory Stimulation (GENUS) is an emerging treatment for neuropsychiatric disorders that uses sensory stimulation to entrain impaired oscillatory network activity and restore brain function. Aberrant oscillatory activity often underlies the symptoms experienced by patients with schizophrenia. We propose that GENUS has therapeutic potential for schizophrenia. This paper reviews the current status of schizophrenia treatment and explores the use of sensory stimulation as an adjunctive treatment, specifically through gamma entrainment. Impaired gamma frequency entrainment is observed in patients, particularly in response to auditory and visual stimuli. Thus, sensory stimulation, such as music listening, may have therapeutic potential for individuals with schizophrenia. GENUS holds novel therapeutic potential to improve the lives of individuals with schizophrenia, but further research is required to determine the efficacy of GENUS, optimize its delivery and therapeutic window, and develop strategies for its implementation in specific patient populations. •GENUS is a novel non-pharmacological therapeutic intervention.•This review examines if GENUS can be applied to schizophrenia.•Specific future research directions in clinical and preclinical models are proposed.
ISSN:0149-7634
1873-7528
1873-7528
DOI:10.1016/j.neubiorev.2024.105681