Long-term follow-up of non-myasthenic patients with early-stage thymoma who underwent extended thymectomy or limited resection

The standard resection for early-stage thymoma is total thymectomy and complete tumour excision with or without myasthenia gravis but the optimal surgery mode for patients with early-stage non-myasthenic thymoma is debatable. This study analysed the oncological outcomes for non-myasthenic patients w...

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Published in:European journal of surgical oncology 2024-06, Vol.50 (6), p.108349-108349, Article 108349
Main Authors: Tsai, Ping-Chung, Tseng, Yen-Chiang, Ting, Ying-Che, Huang, Chien-Sheng, Hsu, Wen-Hu, Tang, En-Kuei, Hsu, Han-Shui
Format: Article
Language:English
Subjects:
Adult
Aged
Extended thymectomy
Female
Follow-Up Studies
Humans
Length of Stay
Limited resection
Male
Middle Aged
Myasthenia Gravis - surgery
Neoplasm Recurrence, Local
Neoplasm Staging
Operative Time
Recurrence
Retrospective Studies
Survival
Survival Rate
Taiwan - epidemiology
Thymectomy - methods
Thymoma
Thymoma - complications
Thymoma - pathology
Thymoma - surgery
Thymus Neoplasms - complications
Thymus Neoplasms - pathology
Thymus Neoplasms - surgery
Treatment Outcome
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Summary:The standard resection for early-stage thymoma is total thymectomy and complete tumour excision with or without myasthenia gravis but the optimal surgery mode for patients with early-stage non-myasthenic thymoma is debatable. This study analysed the oncological outcomes for non-myasthenic patients with early-stage thymoma treated by thymectomy or limited resection in the long term. Patients who had resections of thymic neoplasms at Taipei Veteran General Hospital, Taiwan between December 1997 and March 2013 were recruited, exclusive of those combined clinical evidence of myasthenia gravis were reviewed. A total of 113 patients were retrospectively reviewed with pathologic early stage (Masaoka stage I and II) thymoma who underwent limited resection or extended thymectomy to compare their long-term oncologic and surgical outcomes. The median observation time was 134.1 months [interquartile range (IQR) 90.7–176.1 months]. In our cohort, 52 patients underwent extended thymectomy and 61 patients underwent limited resection. Shorter duration of surgery (p 
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2024.108349