New evidence on the controversy over the correlation between vertebral osteoporosis and intervertebral disc degeneration: a systematic review of relevant animal studies

Objective The effect of vertebral osteoporosis on disc degeneration remains controversial. The aim of this study was to conduct a systematic review and meta-analysis of relevant animal studies to shed more light on the effects and mechanisms of vertebral osteoporosis on disc degeneration and to prom...

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Bibliographic Details
Published in:European spine journal 2024-06, Vol.33 (6), p.2354-2379
Main Authors: Li, Wenhao, Niu, Yiqun, Qiu, Ziye, Zhou, Shibo, Zhong, Wenqing, Xiong, Zhencheng, Zhao, Dingyan, Yang, Yongdong, Zhao, He, Yu, Xing
Format: Article
Language:English
Subjects:
ADAM protein
Aggrecan
Bone remodeling
Collagen
Collagen (type I)
Collagen (type II)
Collagenase 3
Degeneration
Degenerative disc disease
Interstitial collagenase
Intervertebral discs
Matrix metalloproteinase
Medicine
Medicine & Public Health
Meta-analysis
Neurosurgery
Osteoclasts
Osteoporosis
Review Article
Statistical analysis
Stromelysin 1
Surgical Orthopedics
Systematic review
Thrombospondin
Vertebrae
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Summary:Objective The effect of vertebral osteoporosis on disc degeneration remains controversial. The aim of this study was to conduct a systematic review and meta-analysis of relevant animal studies to shed more light on the effects and mechanisms of vertebral osteoporosis on disc degeneration and to promote the resolution of the controversy. Methods The PubMed, Cochrane Library, and Embase databases were searched for studies that met the inclusion criteria. Basic information and data were extracted from the included studies and data were analyzed using STATA 15.1 software. This study was registered on INPLASY with the registration number INPLASY202370099 and https://doi.org/10.37766/inplasy2023.7.0099 . Results A total of 13 studies were included in our study. Both animals, rats and mice, were covered. Meta-analysis results showed in disc height index (DHI) ( P  
ISSN:0940-6719
1432-0932
1432-0932
DOI:10.1007/s00586-024-08256-z