Efficacy of natural enzymes mouthwash: a randomised controlled trial

Objectives Natural enzymes mouthwash has been proposed as salivary substitutes to treat xerostomia. This study aims to evaluate the efficacy of the mouthwash to treat xerostomia. Materials and methods A double-blind, parallel group randomised control clinical trial involving N  = 49 adult participan...

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Published in:Clinical oral investigations 2024-04, Vol.28 (5), p.259-259, Article 259
Main Authors: Chiam, Thao Liang, Choo, Jowayne, Ashar, Atika, Hussaini, Haizal Mohd, Rajandram, Rama Krsna, Nordin, Rifqah
Format: Article
Language:English
Subjects:
Adult
Benzydamine - therapeutic use
Clinical outcomes
Clinical trials
Cognitive ability
Deglutition
Dentistry
Enzymes
Glucose oxidase
Glucose Oxidase - therapeutic use
Humans
Intervention
Lactoferrin
Lysozyme
Medicine
Mouthwashes
Mouthwashes - therapeutic use
Oral hygiene
Speech perception
Xerostomia
Xerostomia - drug therapy
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Summary:Objectives Natural enzymes mouthwash has been proposed as salivary substitutes to treat xerostomia. This study aims to evaluate the efficacy of the mouthwash to treat xerostomia. Materials and methods A double-blind, parallel group randomised control clinical trial involving N  = 49 adult participants with xerostomia was carried out. Intervention group received natural enzymes moisturising mouthwash (with active ingredients lactoferrin, lysozyme, lactoperoxidase and glucose oxidase); while control group received benzydamine mouthwash. Mouthwashes were repacked, labelled with specific code, and were given to participants by third-party. Subjects were instructed to rinse with the mouthwash 4 times per day at a specific period, for 2 weeks. Symptoms of xerostomia were assessed using Xerostomia Inventory at day 0 and 14; together with the assessment of Clinical Oral Dryness Score (CODS), and measurement of resting and stimulated salivary flow rate. Results 48 participants completed the clinical follow-up, and n  = 1 had lost of follow-up. From the 48 participants, n  = 23 received natural enzymes mouthwash, while n  = 25 received benzydamine mouthwash. Intervention group achieved reduction in symptoms of xerostomia from baseline. Intervention group also showed significantly better improvements in the cognitive perception of dry mouth and oromotor function such as chewing, swallowing and speech of the participants; and reduction in waking up at night to drink water ( p  
ISSN:1436-3771
1432-6981
1436-3771
DOI:10.1007/s00784-024-05658-7