Profile, Risk Factors, and Outcomes of Asymptomatic Bacteriuria in Kidney Transplant Recipients with Normal Pretransplant Genitourinary Tract: A Single-Center Experience

• Published in: Indian journal of nephrology 2024-01, Vol.34 (1), p.37-44
• Main Authors: Mani, Selvin Sundar Raj, Thomas, Athul, Alam, Rizwan, Lalwani, Manish, Valson, Anna T, Yadav, Bijesh, Eapen, Jeethu J, John, Elenjickal E, Yusuf, Sabina, Mukha, Rajiv P, Rajadoss, Muthu Krishna Pandian, Mercy, Deborah, Alexander, Suceena, Varughese, Santosh, David, Vinoi G
• Format: Article
• Language: English
• ISSN: 0971-4065; 1998-3662
• DOI: 10.4103/ijn.ijn_407_22

There is a paucity of studies on asymptomatic bacteriuria (ASB) among kidney transplant recipients (KTR) in developing countries. This study assessed the clinical profile, risk factors, outcomes, and impact of treatment of ASB in KTRs with a normal genitourinary tract. Consecutive KTRs from 2009 to 2018 with no clinical or radiological evidence of obstructive uropathy were included. Urinary tract infection (UTI) after ASB was defined as occurrence of cystitis, pyelonephritis, or urosepsis, with ASB being the first bacteriuric episode. Seven hundred ten out of 794 patients with median follow up of 47 months were included. The mean age was 35.5 ± 12 years. Eighty-one patients (11.4%) developed ASB at a median of 25 days (IQR 10, 134.5). Fifty-three percent and 4.9% of ASB episodes were extended-spectrum beta-lactamase (ESBL) positive and carbapenem-resistant organisms, respectively. Eighteen patients (32.1%) with early ASB (