Self-Assembly of Peptides as an Alluring Approach toward Cancer Treatment and Imaging

• Published in: ACS biomaterials science & engineering 2024-05, Vol.10 (5), p.2841-2862
• Main Authors: Ghafoor, Muhammad Hamza, Song, Ben-Li, Zhou, Lei, Qiao, Zeng-Ying, Wang, Hao
• Format: Article
• Language: English
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Drug Delivery Systems - methods; Humans; Neoplasms - diagnostic imaging; Neoplasms - drug therapy; Peptides - chemistry; Peptides - therapeutic use
• ISSN: 2373-9878; 2373-9878
• DOI: 10.1021/acsbiomaterials.4c00491

Cancer is a severe threat to humans, as it is the second leading cause of death after cardiovascular diseases and still poses the biggest challenge in the world of medicine. Due to its higher mortality rates and resistance, it requires a more focused and productive approach to provide the solution for it. Many therapies promising to deliver favorable results, such as chemotherapy and radiotherapy, have come up with more negatives than positives. Therefore, a new class of medicinal solutions and a more targeted approach is of the essence. This review highlights the alluring properties, configurations, and self-assembly of peptide molecules which benefit the traditional approach toward cancer therapy while sparing the healthy cells in the process. As targeted drug delivery systems, self-assembled peptides offer a wide spectrum of conjugation, biocompatibility, degradability-controlled responsiveness, and biomedical applications, including cancer treatment and cancer imaging.