Usefulness of the C-Reactive Protein (CRP)-Albumin-Lymphocyte (CALLY) Index as a Prognostic Indicator for Patients With Gastric Cancer

• Published in: The American surgeon 2024-11, Vol.90 (11), p.2703-2709
• Main Authors: Nakashima, Keigo, Haruki, Koichiro, Kamada, Teppei, Takahashi, Junji, Tsunematsu, Masashi, Ohdaira, Hironori, Furukawa, Kenei, Suzuki, Yutaka, Ikegami, Toru
• Format: Article
• Language: English
• Subjects: Albumin; Biomarkers; Blood tests; Body mass index; Body size; C-reactive protein; Cancer; Cell number; Chemotherapy; Dissection; Gastric cancer; Gastrointestinal surgery; Immunology; Inflammation; Lymphatic system; Lymphocytes; Medical prognosis; Microvasculature; Multivariate analysis; Musculoskeletal system; Neutrophils; Nutrition; Patients; Prognosis; Proteins; Serum albumin; Survival
• ISSN: 0003-1348; 1555-9823; 1555-9823
• DOI: 10.1177/00031348241248693

Background The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel immune nutrition scoring system associated with cancer prognosis. This study investigated the association between the CALLY index and the long-term outcomes of patients with gastric cancer. Methods We included 175 patients with gastric cancer who underwent curative gastrectomies at the Department of Surgery, International University of Health and Welfare Hospital between January 2011 and October 2019. The CALLY index was calculated based on the levels of serum albumin, serum CRP, and peripheral lymphocyte count. Utilizing both univariate and multivariate analyses, the prognostic value of the CALLY index was investigated. Results In the multivariate analyses, disease stage (hazard ratio [HR], 7.85; 95% confidence interval [CI], 3.31-18.6; P < .01), microvascular invasion (HR, 2.88; 95% CI, 1.30-6.36; P < .01), and low CALLY index (HR, 2.18; 95% CI, 1.00-4.76; P = .05) were independent and significant predictors of disease-free survival. Low body mass index (HR, 4.15; 95% CI, 1.63-10.6; P < .01), advanced disease stage (HR, 8.22; 95% CI, 3.47-19.5; P < .01), and low CALLY index (HR, 3.00; 95% CI, 1.3-6.93; P = .01) were independent and significant predictors of overall survival. The low CALLY index group had a lower body mass index (P < .01), advanced disease stage (P < .01), and a higher Glasgow prognostic score (P < .01). Conclusions The CALLY index may be associated with a poor prognosis for gastric cancer, highlighting the utility of a comprehensive assessment using inflammatory, nutritional, and immunological statuses.