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Determination of the reference interval for urine kidney injury molecule-1 in 50 healthy cats

Objectives The aim of the present study was to establish a reference interval (RI) for urine kidney injury molecule-1 (KIM-1) in healthy cats. Methods History, physical examination, blood pressure, and feline immunodeficiency virus and feline leukemia virus serology status were determined. A complet...

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Bibliographic Details
Published in:Journal of feline medicine and surgery 2024-04, Vol.26 (4), p.1098612X241238923
Main Authors: Brown, Tori, Defarges, Alice, Monteith, Gabrielle, Appleby, Ryan, Bienzle, Dorothee
Format: Article
Language:English
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Summary:Objectives The aim of the present study was to establish a reference interval (RI) for urine kidney injury molecule-1 (KIM-1) in healthy cats. Methods History, physical examination, blood pressure, and feline immunodeficiency virus and feline leukemia virus serology status were determined. A complete blood cell count, serum biochemical profile, urinalysis and kidney ultrasound were performed, and N-terminal pro-brain natriuretic peptide, total thyroxine (TT4) and urine KIM-1 were measured. An RI was calculated and the effect of age, sex, body condition score (BCS), blood pressure, symmetric dimethylarginine (SDMA), serum creatinine concentration (SCr), phosphorus, TT4, urine specific gravity (USG) and mid-sagittal kidney length on urine KIM-1 was evaluated using a general linear model. Results Of 69 recruited cats, 50 met the inclusion criteria. There were 35 male cats and 15 female cats, with a median age of 4.3 years (range 1.0–12.3), median weight of 5.11 kg (range 2.52–8.45) and median BCS of 6/9 (range 3–8). The median serum concentrations were SDMA 11.0 µg/dl (range 2–14), SCr 88.5 µmol/l (range 47–136), phosphorus 1.41 mmol/l (range 0.8–2.2) and TT4 32.0 nmol/l (range 17–51). Median USG was 1.057 (range 1.035–1.076), mid-sagittal left kidney length was 3.50 cm (range 2.94–4.45) and mid-sagittal right kidney length was 3.70 cm (range 3.06–4.55). The derived RI for urine KIM-1 was 0.02–0.68. USG was a significant (P
ISSN:1098-612X
1532-2750
1532-2750
DOI:10.1177/1098612X241238923