Ultrasonic synthesis of green lipid nanocarriers loaded with Scutellaria barbata extract: a sustainable approach for enhanced anticancer and antibacterial therapy

• Published in: Bioprocess and biosystems engineering 2024-08, Vol.47 (8), p.1321-1334
• Main Authors: Jetti, Raghu, Vaca Cárdenas, Maritza Lucia, Al-Saedi, Haider Falih Shamikh, Hussein, Shaymaa Abed, Abdulridui, Hussam Abdali, Al-Abdeen, Salah Hassan Zain, Radi, Usama Kadem, Abdulkadhim, Adnan Hashim, Hussein, Sahar Balkit, Alawadi, Ahmed, Alsalamy, Ali
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anticancer properties; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Bioavailability; Biotechnology; Cancer; Chemistry; Chemistry and Materials Science; Cholesterol; Controlled release; Drug carriers; Drug Carriers - chemistry; Drug delivery; Drug development; Effectiveness; Encapsulation; Environmental Engineering/Biotechnology; Food Science; Green Chemistry Technology; Humans; Industrial and Production Engineering; Industrial Chemistry/Chemical Engineering; Light scattering; Lipids; Lipids - chemistry; Manufacturing; Manufacturing industry; Medical innovations; Nanoparticles - chemistry; Nanotechnology; Photon correlation spectroscopy; Plant Extracts - chemistry; Pseudomonas aeruginosa - drug effects; Research Paper; Scutellaria - chemistry; Scutellaria barbata; Self-assembly; Stability augmentation; Sustainable practices; Synthesis; Transmission electron microscopy; Ultrasonic Waves; Ultrasonics; Zeta potential
• ISSN: 1615-7591; 1615-7605; 1615-7605
• DOI: 10.1007/s00449-024-03021-4

Ultrasonic manufacturing has emerged as a promising eco-friendly approach to synthesize lipid-based nanocarriers for targeted drug delivery. This study presents the novel ultrasonic preparation of lipid nanocarriers loaded with Scutellaria barbata extract, repurposed for anticancer and antibacterial use. High-frequency ultrasonic waves enabled the precise self-assembly of DSPE-PEG, Span 40, and cholesterol to form nanocarriers encapsulating the therapeutic extract without the use of toxic solvents, exemplifying green nanotechnology. Leveraging the inherent anticancer and antibacterial properties of Scutellaria barbata , the study demonstrates that lipid encapsulation enhances the bioavailability and controlled release of the extract, which is vital for its therapeutic efficacy. Dynamic light scattering and transmission electron microscopy analyses confirmed the increase in size and successful encapsulation post-loading, along with an augmented negative zeta potential indicating enhanced stability. A high encapsulation efficiency of 91.93% was achieved, and in vitro assays revealed the loaded nanocarriers’ optimized release kinetics and improved antimicrobial potency against Pseudomonas aeruginosa , compared to the free extract. The combination of ultrasonic synthesis and Scutellaria barbata in an eco-friendly manufacturing process not only advances green nanotechnology but also contributes to sustainable practices in pharmaceutical manufacturing. The data suggest that this innovative nanocarrier system could provide a robust platform for the development of nanotechnology-based therapeutics, enhancing drug delivery efficacy while aligning with environmental sustainability.