Obesity and dyslipidemia in early life: Impact on cardiometabolic risk

• Published in: Metabolism, clinical and experimental clinical and experimental, 2024-07, Vol.156, p.155919, Article 155919
• Main Authors: Zeljkovic, Aleksandra, Vekic, Jelena, Stefanovic, Aleksandra
• Format: Article
• Language: English
• Subjects: Cardiometabolic risk; Cardiometabolic Risk Factors; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cardiovascular Diseases - metabolism; Child; Childhood obesity; Dyslipidemia; Dyslipidemias - etiology; Dyslipidemias - metabolism; Epigenesis, Genetic; Female; Humans; Lipid biomarkers; Maternal metabolism; Obesity - complications; Obesity - metabolism; Pediatric Obesity - complications; Pediatric Obesity - metabolism; Pregnancy; Prenatal Exposure Delayed Effects - metabolism; Risk Factors
• ISSN: 0026-0495; 1532-8600; 1532-8600
• DOI: 10.1016/j.metabol.2024.155919

Childhood obesity with its growing prevalence worldwide presents one of the most important health challenges nowadays. Multiple mechanisms are involved in the development of this condition, as well as in its associations with various cardiometabolic complications, such as insulin resistance, diabetes, metabolic dysfunction-associated steatotic liver disease and cardiovascular diseases. Recent findings suggest that childhood obesity and associated dyslipidemia at least partly originate from epigenetic modifications that take place in the earliest periods of life, namely prenatal and perinatal periods. Hence, alterations of maternal metabolism could be fundamentally responsible for fetal and neonatal metabolic programming and consequently, for metabolic health of offspring in later life. In this paper, we will review recent findings on the associations among intrauterine and early postnatal exposure to undesirable modulators of metabolism, development of childhood obesity and later cardiometabolic complications. Special attention will be given to maternal dyslipidemia as a driven force for undesirable epigenetic modulations in offspring. In addition, newly proposed lipid biomarkers of increased cardiometabolic risk in obese children and adolescents will be analyzed, with respect to their predictive potential and clinical applicability. [Display omitted] •Childhood obesity poses short-term and long-term impact on cardiometabolic health.•Maternal dyslipidemia could predispose offspring to obesity.•Obesity-related dyslipidemia in childhood increases cardiometabolic risk in adulthood.•Omics-based biomarkers could improve evaluation of dyslipidemia in childhood.