Therapeutic effects of ginsenosides on osteoporosis for novel drug applications

Osteoporosis (OP) is a metabolic bone disease with a high incidence rate worldwide. Its main features are decreased bone mass, increased bone fragility and deterioration of bone microstructure. It is caused by an imbalance between bone formation and bone resorption. Ginsenoside is a safe and effecti...

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Bibliographic Details
Published in:European journal of pharmacology 2024-07, Vol.974, p.176604, Article 176604
Main Authors: Liu, Rui, Xu, Li-Xia, Tong, Lin-Jian, Wu, Hai-Yang, Guo, Qiang, Sun, Zhi-Ming, Yan, Hua
Format: Article
Language:English
Subjects:
Animals
Bone marrow stromal cells
Bone Remodeling - drug effects
Ginsenosides
Ginsenosides - pharmacology
Ginsenosides - therapeutic use
Humans
Osteoblasts
Osteoblasts - drug effects
Osteoclasts
Osteoclasts - drug effects
Osteoporosis
Osteoporosis - drug therapy
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Summary:Osteoporosis (OP) is a metabolic bone disease with a high incidence rate worldwide. Its main features are decreased bone mass, increased bone fragility and deterioration of bone microstructure. It is caused by an imbalance between bone formation and bone resorption. Ginsenoside is a safe and effective traditional Chinese medicine (TCM) usually extracted from ginseng plants, having various therapeutic effects, of which the effect against osteoporosis has been extensively studied. We searched a total of 44 relevant articles with using keywords including osteoporosis, ginsenosides, bone mesenchymal cells, osteoblasts, osteoclasts and bone remodeling, all of which investigated the cellular mechanisms of different types of ginsenosides affecting the activity of bone remodeling by mesenchymal stem cells, osteoblasts and osteoclasts to counteract osteoporosis. This review describes the different types of ginsenosides used to treat osteoporosis from different perspectives, providing a solid theoretical basis for future clinical applications.
ISSN:0014-2999
1879-0712
1879-0712
DOI:10.1016/j.ejphar.2024.176604