Pneumocystis jirovecii Pneumonia Complicating Use of Upadacitinib in a Patient With Ulcerative Colitis and Primary Sclerosing Cholangitis: A Case Report

Lay Summary Pneumocystis jirovecii is a ubiquitous, unicellular fungus that can cause pneumonia (PJP) in immunosuppressed individuals. We report the first case of PJP complicating upadacitinib use for ulcerative colitis. This report is of clinical relevance given the widespread uptake of JAK inhibit...

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Bibliographic Details
Published in:Inflammatory bowel diseases 2024-08, Vol.30 (8), p.1435-1436
Main Authors: Chin, Simone, Fox, Lucy, Majumdar, Avik, Oliver, Mark, Choy, Matthew C, De Cruz, Peter
Format: Article
Language:English
Subjects:
Cholangitis, Sclerosing - complications
Cholangitis, Sclerosing - drug therapy
Colitis, Ulcerative - complications
Colitis, Ulcerative - drug therapy
Female
Heterocyclic Compounds, 3-Ring - adverse effects
Humans
Male
Middle Aged
Pneumocystis carinii
Pneumonia, Pneumocystis - chemically induced
Pneumonia, Pneumocystis - drug therapy
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Summary:Lay Summary Pneumocystis jirovecii is a ubiquitous, unicellular fungus that can cause pneumonia (PJP) in immunosuppressed individuals. We report the first case of PJP complicating upadacitinib use for ulcerative colitis. This report is of clinical relevance given the widespread uptake of JAK inhibition.
ISSN:1078-0998
1536-4844
1536-4844
DOI:10.1093/ibd/izae091