Mesoporous Gold: Substrate‐Dependent Growth Dynamics, Strain Accumulation, and Electrocatalytic Activity for Biosensing

Understanding the growth of mesoporous crystalline materials, such as mesoporous metals, on different substrates can provide valuable insights into the crystal growth dynamics and the redox reactions that influence their electrochemical sensing performance. Herein, it is demonstrated how the amorpho...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-08, Vol.20 (35), p.e2311645-n/a
Main Authors: Park, Hyeongyu, Masud, Mostafa Kamal, Ashok, Aditya, Kim, Minjun, Wahab, Md Abdul, Zhou, Jun, Terasawa, Yukana, Gallo, Carlos Salomon, Nguyen, Nam‐Trung, Hossain, Md Shahriar A., Yamauchi, Yusuke, Kaneti, Yusuf Valentino
Format: Article
Language:English
Subjects:
Accumulation
Amorphous materials
Biomolecules
Biosensing Techniques - methods
biosensors
Catalysis
Chemical reactions
COVID-19 - diagnosis
COVID-19 - virology
Crystal defects
Crystal growth
Electrochemical analysis
electrochemical sensing
Electrochemical Techniques - methods
Glass substrates
Gold
Gold - chemistry
lattice expansion
Limit of Detection
mesoporous gold
Porosity
Redox reactions
RNA, Viral
SARS-CoV-2 - isolation & purification
SARS‐CoV‐2
strain engineering
Surface defects
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Summary:Understanding the growth of mesoporous crystalline materials, such as mesoporous metals, on different substrates can provide valuable insights into the crystal growth dynamics and the redox reactions that influence their electrochemical sensing performance. Herein, it is demonstrated how the amorphous nature of the glass substrate can suppress the typical oriented growth in mesoporous Au (mAu) films. The suppressed growth is manifested as an accumulation of strain, leading to the generation of abundant surface defects, which are beneficial for enhancing the electrochemical activity. The fine structuring attained enables dramatically accelerated diffusion and enhances the electrochemical sensing performance for disease‐specific biomolecules. As a proof‐of‐concept, the as‐fabricated glass‐grown mAu film demonstrates high sensitivity in electrochemical detection of SARS‐CoV‐2‐specific RNA with a limit of detection (LoD) as low as 1 attomolar (aM). Mesoporous Au grown on the glass substrate can suppress the typical oriented growth of Au and possesses a unique jagged structure with more exposed active sites and surface roughness for ultrasensitive detection of RNA biomarkers.
ISSN:1613-6810
1613-6829
1613-6829
DOI:10.1002/smll.202311645