Ultrastructural, molecular and haemato-immunological changes: Multifaceted toxicological effects of microcystin-LR in rohu, Labeo rohita

No water body is resilient to afflicts of algal bloom, if goes unmanaged. With the increasing trend of intensification, eutrophication and climate change, Labeo rohita (rohu) is highly anticipated to suffer from the deleterious effects of bloom and eventually its toxins. A comprehensive study was co...

Full description

Saved in:
Bibliographic Details
Published in:Chemosphere (Oxford) 2024-06, Vol.358, p.142097-142097, Article 142097
Main Authors: Mohanty, Snatashree, Paul, Anirban, Banerjee, Sagar, Rajendran, K.V., Tripathi, Gayatri, Das, Pratap Chandra, Sahoo, Pramoda Kumar
Format: Article
Language:English
Subjects:
Acute toxicity
Apoptosis
Labeo rohita
Microcystin-LR
Pathophysiology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:No water body is resilient to afflicts of algal bloom, if goes unmanaged. With the increasing trend of intensification, eutrophication and climate change, Labeo rohita (rohu) is highly anticipated to suffer from the deleterious effects of bloom and eventually its toxins. A comprehensive study was conducted to understand the toxicopathological effects of microcystin-LR (MC-LR) in rohu following intraperitoneal injection of 96 h-LD50 dose i.e., 713 μg kg−1. Substantial changes in micro- and ultrastructural level were evident in histopathology and transmission electron microscope (TEM) study. The haematological, biochemical, cellular and humoral innate immune biomarkers were significantly altered (p 
ISSN:0045-6535
1879-1298
DOI:10.1016/j.chemosphere.2024.142097