Changes on corpus luteum structure and progesterone synthesis pathway after hCG or GnRH treatment during the early luteal phase in sheep

This study investigated the effect of hCG or GnRH on structural changes of the corpora lutea (CL) and the regulation of the expression of steroidogenic enzymes involved in P4 secretion in post-ovulatory (po-CL) and accessory CL (acc-CL). Sixty-four ewes were assigned to three groups receiving: 300 I...

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Published in:Animal reproduction science 2024-06, Vol.265, p.107474, Article 107474
Main Authors: Fernández, Jimena, Bruno-Galarraga, María Macarena, Cueto, Marcela Isabel, Bonadeo, Nadia, Notaro, Ulises, Soto, Andrés Telésforo, de la Sota, Rodolfo Luzbel, Salvetti, Natalia Raquel, Bianchi, Carolina Paula, Cristina, Carolina, Ortega, Hugo Héctor, Gibbons, Alejandro Eduardo, Lacau-Mengido, Isabel María
Format: Article
Language:English
Subjects:
Accessory corpora lutea
Animals
Cholesterol Side-Chain Cleavage Enzyme - genetics
Cholesterol Side-Chain Cleavage Enzyme - metabolism
Chorionic Gonadotropin - administration & dosage
Chorionic Gonadotropin - pharmacology
Corpus Luteum - drug effects
Corpus Luteum - metabolism
Ewes
Female
Gonadotropin-Releasing Hormone - metabolism
Gonadotropin-Releasing Hormone - pharmacology
Luteal cell
Luteal function
Luteal Phase - drug effects
Luteinizing Hormone - metabolism
Phosphoproteins
Progesterone - blood
Progesterone - metabolism
Sheep - physiology
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cited_by cdi_FETCH-LOGICAL-c377t-1a65924534ad4567dce6aaab4b41a7f665605bf65e3c746df431540fcf3b087b3
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container_start_page 107474
container_title Animal reproduction science
container_volume 265
creator Fernández, Jimena
Bruno-Galarraga, María Macarena
Cueto, Marcela Isabel
Bonadeo, Nadia
Notaro, Ulises
Soto, Andrés Telésforo
de la Sota, Rodolfo Luzbel
Salvetti, Natalia Raquel
Bianchi, Carolina Paula
Cristina, Carolina
Ortega, Hugo Héctor
Gibbons, Alejandro Eduardo
Lacau-Mengido, Isabel María
description This study investigated the effect of hCG or GnRH on structural changes of the corpora lutea (CL) and the regulation of the expression of steroidogenic enzymes involved in P4 secretion in post-ovulatory (po-CL) and accessory CL (acc-CL). Sixty-four ewes were assigned to three groups receiving: 300 IU of hCG (hCG) or 4 µg Buserelin (GnRH) or 1 mL of saline solution (Control) on Day (d) 4 post artificial insemination (FTAI). Laparoscopic ovarian were performed on d 4, 14 and, 21 post-FTAI to determine the numbers of CL. Blood samples were collected for serum LH and P4 analysis. On d 14 post-FTAI, both CL were removed from the ovary to determine large luteal cell (LLC) number and to evaluate the expression of steroidogenic enzymes (HSD3B1, STAR, CYP11A1). Only hCG and GnRH treated ewes generated acc-CL. The LLC in both po- and acc-CL were significantly greater in the hCG group compared to GnRH and Control groups (P
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Sixty-four ewes were assigned to three groups receiving: 300 IU of hCG (hCG) or 4 µg Buserelin (GnRH) or 1 mL of saline solution (Control) on Day (d) 4 post artificial insemination (FTAI). Laparoscopic ovarian were performed on d 4, 14 and, 21 post-FTAI to determine the numbers of CL. Blood samples were collected for serum LH and P4 analysis. On d 14 post-FTAI, both CL were removed from the ovary to determine large luteal cell (LLC) number and to evaluate the expression of steroidogenic enzymes (HSD3B1, STAR, CYP11A1). Only hCG and GnRH treated ewes generated acc-CL. The LLC in both po- and acc-CL were significantly greater in the hCG group compared to GnRH and Control groups (P&lt;0.05). Overall, hCG group showed the greatest immunodetection of HSD3B1and STAR in both po- and acc-CL (P&lt;0.05). rnRNA expression of HSD3B1, STAR and CYP11A1 in the acc-CL tended to be greater in hCG group than in GnRH group (P&lt;0.1). 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Sixty-four ewes were assigned to three groups receiving: 300 IU of hCG (hCG) or 4 µg Buserelin (GnRH) or 1 mL of saline solution (Control) on Day (d) 4 post artificial insemination (FTAI). Laparoscopic ovarian were performed on d 4, 14 and, 21 post-FTAI to determine the numbers of CL. Blood samples were collected for serum LH and P4 analysis. On d 14 post-FTAI, both CL were removed from the ovary to determine large luteal cell (LLC) number and to evaluate the expression of steroidogenic enzymes (HSD3B1, STAR, CYP11A1). Only hCG and GnRH treated ewes generated acc-CL. The LLC in both po- and acc-CL were significantly greater in the hCG group compared to GnRH and Control groups (P&lt;0.05). Overall, hCG group showed the greatest immunodetection of HSD3B1and STAR in both po- and acc-CL (P&lt;0.05). rnRNA expression of HSD3B1, STAR and CYP11A1 in the acc-CL tended to be greater in hCG group than in GnRH group (P&lt;0.1). The LH concentration was increased in GnRH group (P&lt;0.05) and P4 concentration was greater in hCG group compared to the other groups (P&lt;0.05). In conclusion, administration of hCG has a notably impact on acc-CL development and the expression of steroidogenic enzymes compared to GnRH treatment in ewes. This leads to elevated P4 concentration and improved luteal function. •GnRH or hCG treatments generate CL with different histo-functional characteristics.•The serum P4 concentration increased in ewes treated with hCG that generated an accessory CL.•hCG treatment generated an accessory CL with greater number of large luteal cells.•3 β-HSD, STAR and Cyt- P450 were higher in accessory CL of ewes treated with hCG.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38657463</pmid><doi>10.1016/j.anireprosci.2024.107474</doi><orcidid>https://orcid.org/0000-0002-9125-9282</orcidid><orcidid>https://orcid.org/0000-0002-9052-8356</orcidid><orcidid>https://orcid.org/0000-0003-2547-3819</orcidid></addata></record>
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subjects Accessory corpora lutea
Animals
Cholesterol Side-Chain Cleavage Enzyme - genetics
Cholesterol Side-Chain Cleavage Enzyme - metabolism
Chorionic Gonadotropin - administration & dosage
Chorionic Gonadotropin - pharmacology
Corpus Luteum - drug effects
Corpus Luteum - metabolism
Ewes
Female
Gonadotropin-Releasing Hormone - metabolism
Gonadotropin-Releasing Hormone - pharmacology
Luteal cell
Luteal function
Luteal Phase - drug effects
Luteinizing Hormone - metabolism
Phosphoproteins
Progesterone - blood
Progesterone - metabolism
Sheep - physiology
title Changes on corpus luteum structure and progesterone synthesis pathway after hCG or GnRH treatment during the early luteal phase in sheep
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