Cost-utility analysis of adjunct repetitive transcranial magnetic stimulation for treatment resistant bipolar depression

• Published in: Journal of affective disorders 2024-07, Vol.356, p.639-646
• Main Authors: Chatterton, Mary Lou, Lee, Yong Yi, Le, Long Khanh-Dao, Nichols, Melanie, Carter, Rob, Berk, Michael, Mihalopoulos, Cathrine
• Format: Article
• Language: English
• Subjects: Adult; Australia; Bipolar disorder; Bipolar Disorder - economics; Bipolar Disorder - therapy; Combined Modality Therapy; Cost-Benefit Analysis; Depression; Depressive Disorder, Treatment-Resistant - economics; Depressive Disorder, Treatment-Resistant - therapy; Female; Health economics; Health outcomes; Humans; Mental health; Models, Economic; Mood disorders; Psychiatry; Quality-Adjusted Life Years; Transcranial Magnetic Stimulation - economics; Transcranial Magnetic Stimulation - methods
• ISSN: 0165-0327; 1573-2517
• DOI: 10.1016/j.jad.2024.04.075

To evaluate the cost-effectiveness of repetitive transcranial magnetic stimulation (rTMS) as an adjunct to standard care from an Australian health sector perspective, compared to standard care alone for adults with treatment-resistant bipolar depression (TRBD). An economic model was developed to estimate the cost per disability-adjusted life-year (DALY) averted and quality-adjusted life-year (QALY) gained for rTMS added to standard care compared to standard care alone, for adults with TRBD. The model simulated the time in three health states (mania, depression, residual) over one year. Response to rTMS was sourced from a meta-analysis, converted to a relative risk and used to modify the time in the depressed state. Uncertainty and sensitivity tested the robustness of results. Base-case incremental cost-effectiveness ratios (ICERs) were $72,299 per DALY averted (95 % Uncertainty Interval (UI): $60,915 to $86,668) and $46,623 per QALY gained (95 % UI: $39,676 - $55,161). At a willingness to pay (WTP) threshold of $96,000 per DALY averted, the base-case had a 100 % probability of being marginally cost-effective. At a WTP threshold of $64,000 per QALY gained, the base-case had a 100 % probability of being cost-effective. Sensitivity analyses decreasing the number of sessions provided, increasing the disability weight or the time spent in the depression state for standard care improved the ICERs for rTMS. Dependent on the outcome measure utilised and assumptions, rTMS would be considered a very cost-effective or marginally cost-effective adjunct to standard care for TRBD compared to standard care alone. •The cost-effectiveness of repetitive transcranial magnetic stimulation (rTMS) added to standard care for treatment resistant bipolar depression (TRBD) was estimated.•The economic model used the available efficacy data on rTMS and standard care for TRBD.•rTMS was estimated to decrease morbidity at an additional cost.•rTMS was considered cost-effective for TRBD.