Evaluating the impact of the degree of extranodal extension on outcomes in locally advanced oral cavity cancer

• Published in: Head & neck 2024-09, Vol.46 (9), p.2340-2347
• Main Authors: Yalamanchali, Anirudh, Griffith, Christopher, Reddy, Chandana A., Koyfman, Shlomo A., Woody, Neil M., Campbell, Shauna R., Silver, Natalie, Scharpf, Joseph, Lorenz, Robert R., Prendes, Brandon, Ku, Jamie A., Lamarre, Eric, Geiger, Jessica L.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Carcinoma, Squamous Cell - therapy; Disease-Free Survival; extranodal extension; Extranodal Extension - pathology; Female; Head & neck cancer; Humans; Male; Middle Aged; Mouth Neoplasms - mortality; Mouth Neoplasms - pathology; Mouth Neoplasms - surgery; Mouth Neoplasms - therapy; Neoplasm Staging; Oral carcinoma; Oral cavity; oral cavity cancer; Proportional Hazards Models; Retrospective Studies; Squamous cell carcinoma; squamous cell carcinoma of head and neck; Treatment Outcome
• ISSN: 1043-3074; 1097-0347; 1097-0347
• DOI: 10.1002/hed.27782

Background Evaluate whether extranodal extension (ENE) extent impacts outcomes in patients with oral cavity squamous cell carcinoma (OCSCC). Methods From an institutional database, patients with OCSCC and pathologic ENE who received adjuvant treatment were included. Surgical slides were reviewed to confirm ENE extent. Multivariable Cox regression was used to relate patient/treatment characteristics with disease‐free survival (DFS) and overall survival (OS). ENE was analyzed as both a dichotomous and continuous variable. Results A total of 113 patients were identified. Between major (>2 mm) versus minor ENE (≤2 mm), there was no significant difference in DFS (HR 1.18, 95%CI 0.72–1.92, p = 0.51) or OS (HR 1.17, 95%CI 0.70–1.96, p = 0.55). There was no significant association between ENE as a continuous variable and DFS (HR 0.97 per mm, 95%CI 0.87–1.4, p = 0.96) or OS (HR 0.96 per mm, 95%CI 0.83–1.11, p = 0.58). Conclusion No significant relationship was seen between ENE extent and DFS or OS in individuals with OCSCC.