Growth differentiation factor-15 and metabolic features in chronic heart failure: Insights from the SUPPORT Trial -GDF15 across the BMI spectrum

GDF15 plays pivotal metabolic roles in nutritional stress and serves as a physiological regulator of energy balance. However, the patterns of GDF15 levels in underweight or obese patients with chronic heart failure (CHF) are not well-understood. We assessed serum GDF15 levels at baseline and 3 years...

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Bibliographic Details
Published in:International journal of cardiology 2024-07, Vol.407, p.132093-132093, Article 132093
Main Authors: Teramoto, Kanako, Nochioka, Kotaro, Sakata, Yasuhiko, Kato, Eri Toda, Nishimura, Kunihiro, Shimokawa, Hiroaki, Yasuda, Satoshi
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Body Mass Index
Cachexia
Chronic Disease
Chronic heart failure
Female
Follow-Up Studies
Growth Differentiation Factor 15 - blood
Growth differentiation factor-15
Heart Failure - blood
Heart Failure - epidemiology
Humans
Male
Middle Aged
Obesity
Obesity - blood
Obesity - epidemiology
Thinness - blood
Thinness - epidemiology
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Summary:GDF15 plays pivotal metabolic roles in nutritional stress and serves as a physiological regulator of energy balance. However, the patterns of GDF15 levels in underweight or obese patients with chronic heart failure (CHF) are not well-understood. We assessed serum GDF15 levels at baseline and 3 years and the temporal changes in 940 Japanese patients (642 paired samples), as a sub-analysis of the SUPPORT trial (age 65.9 ± 10.1 years). The GDF15 levels were analyzed across BMI groups (underweight [
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2024.132093