Meta-analysis of nano-phytosomes: unleashing the potential of plant-derived compounds for advancing cancer therapy

• Published in: Natural product research 2024-04, p.1-20
• Main Authors: Al-Samydai, Ali, Nsairat, Hamdi, Abu Hajleh, Maha N, Aburas, Bayan, Akour, Amal, Ata, Tha'er Husam, Mahmood, Tabarek H, Al-Sammarraie, Tabarak Riyadh, Atta, Rawan, Ali, Rahaf, Alazzawi, Qasim Khalid, Aburjai, Ahmed, Carradori, Simone
• Format: Article
• Language: English
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2024.2344182

Nano-phytosomes are considered as an efficient drug delivery system for phytochemicals. Phytosomes enhance stability and significantly improves phytochemicals bioavailability and therapeutic efficacy. Thorough meta-analysis of 93 articles, phytochemical versus phytosomes size, charge, polydispersity index (PDI) and IC values were investigated. Multivariate Analysis of Covariance revealed significant phytochemicals type effects, even when accounting for cancer cell type and phospholipid type as covariates. Least Significant Difference (LSD) tests described unique attributes among various phytosomes. Flavonoid-based phytosomes exhibited larger particle sizes than others. In contrast, terpenoid-based phytosomes displayed significantly lower charges. Flavonoids demonstrated higher poly dispersity index (PDI) values than alkaloids and polyphenols. Alkaloids exhibited more extensive PDI values, while polyphenols had lower PDI values than terpenoids. Furthermore, flavonoid-containing nanoparticles exhibited higher IC values than terpenoids. In conclusion, nano-phytosomes offer promising prospects for revolutionising drug delivery methodologies and advancing the development of innovative therapeutic solutions in the domain of cancer therapy.