An NIR-II-emitting type-I photosensitizer for efficient hypoxic tumor phototheranostics

A small molecule-based NIR-II type-I photosensitizer (IT-IC) with a strong push-pull effect and good planar π-conjugated structure was synthesized. The IT-IC NPs exhibited strong light absorption, outstanding NIR-II fluorescence emission, excellent photothermal conversion and efficient type-I/II ROS...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-05, Vol.6 (4), p.5322-5325
Main Authors: Wang, Qi, Wang, Ruoqing, Wang, Xiaoyuan, Fu, Mingxuan, Gao, Yicong, Feng, Jianfeng, Geng, Renyong, Yuan, Zhen, Fan, Quli, Lu, Feng
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Cell Survival - drug effects
Electromagnetic absorption
Humans
Infrared Rays
Mice
Molecular Structure
Nanoparticles - chemistry
Neoplasms - drug therapy
Neoplasms - pathology
Photochemotherapy
Photosensitizing Agents - chemical synthesis
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Photothermal conversion
Reactive Oxygen Species - metabolism
Theranostic Nanomedicine
Tumor Hypoxia - drug effects
Tumors
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Summary:A small molecule-based NIR-II type-I photosensitizer (IT-IC) with a strong push-pull effect and good planar π-conjugated structure was synthesized. The IT-IC NPs exhibited strong light absorption, outstanding NIR-II fluorescence emission, excellent photothermal conversion and efficient type-I/II ROS generation, showing encouraging therapeutic outcomes for hypoxic tumors. An NIR-II-emitting type-I photosensitizer with a strong push-pull effect and good planar π-conjugated structure was synthesized for efficient hypoxic tumor phototheranostics.
ISSN:1359-7345
1364-548X
DOI:10.1039/d4cc00431k