New insights from bidirectional Mendelian randomization: causal relationships between telomere length and mitochondrial DNA copy number in aging biomarkers

Mitochondrial DNA (mtDNA) copy number and telomere length (TL) are dynamic factors that have been linked to the aging process in organisms. However, the causal relationship between these variables remains uncertain. In this research, instrumental variables (IVs) related to mtDNA copy number and TL w...

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Bibliographic Details
Published in:Aging (Albany, NY.) NY.), 2024-04, Vol.16 (8), p.7387
Main Authors: Yan, Xinyu, Yang, Peixuan, Li, Yani, Liu, Ting, Zha, Yawen, Wang, Ting, Zhang, Jingjing, Feng, Zhijun, Li, Minying
Format: Article
Language:English
Subjects:
Aging - genetics
Biomarkers
DNA Copy Number Variations
DNA, Mitochondrial - genetics
Genome-Wide Association Study
Humans
Mendelian Randomization Analysis
Telomere - genetics
Telomere Homeostasis - genetics
Telomere Shortening - genetics
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Summary:Mitochondrial DNA (mtDNA) copy number and telomere length (TL) are dynamic factors that have been linked to the aging process in organisms. However, the causal relationship between these variables remains uncertain. In this research, instrumental variables (IVs) related to mtDNA copy number and TL were obtained from publicly available genome-wide association studies (GWAS). Through bidirectional Mendelian randomization (MR) analysis, we examined the potential causal relationship between these factors. The forward analysis, with mtDNA copy number as the exposure and TL as the outcome, did not reveal a significant effect ( =-0.004, >0.05). On the contrary, upon conducting a reverse analysis, it was found that there exists a positive causal relationship ( =0.054,
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.205765