Effect of hydroxy propyl cellulose grade and foam quality on foam granulation of a high drug load formulation

• Published in: International journal of pharmaceutics 2024-05, Vol.657, p.124171-124171, Article 124171
• Main Authors: Koo, Otilia, Patel, Chandrakant, Nikfar, Faranak
• Format: Article
• Language: English
• Subjects: Cellulose - analogs & derivatives; Cellulose - chemistry; Chemistry, Pharmaceutical - methods; Drug Compounding - methods; Excipients - chemistry; Foam granulation; Foam quality; High drug-load formulation; Hydroxypropyl cellulose; Particle Size; Powders - chemistry; Viscosity; Water - chemistry
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2024.124171

[Display omitted] Foam granulation is a relatively newer wet granulation process whereby foamed binder solutions are added to the powders in the mixer to reduce localized over-wetting encountered during the wet granulation. This study is the first to investigate the effect of binder grade and foam quality on foam granulation process and granule properties of a high drug load formulation. Two different HPC grades, HPC LF (two times more viscous) and HPC EXF at an equivalent 7.4%w/w solution concentration, and foam quality of 50%, 90% and binder solution dripped were added to a high drug load (81%w/w) formulation for wet granulation. The granules were evaluated for compactibility and resultant compact strengths. The 50% foam quality of either HPC LF and HPC EXF resulted in lowest impeller power reading and water activity compared to 90% foam quality or dripped HPC solution. Granules prepared with 50% foam quality also exhibited smaller granule size, wider size distribution and higher specific surface area, resulting in higher compactibility. Whilst the granules prepared with different foamed HPC grades were not significantly different in compression behavior, they were higher in compact strengths, suggesting that foam mixing was more efficient in binder distribution compared to binder liquid penetration and distribution.