Association between Platelet-Derived Growth Factor Receptor Alpha Gene Polymorphisms and Platelet-Rich Plasma's Efficiency in Treating Lateral Elbow Tendinopathy-A Prospective Cohort Study

Individual differences in the response to platelet-rich plasma (PRP) therapy can be observed among patients. The genetic background may be the cause of this variability. The current study focused on the impact of genetic variants on the effectiveness of PRP. The aim of the present study was to analy...

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Published in:International journal of molecular sciences 2024-04, Vol.25 (8), p.4266
Main Authors: Jarosz, Alicja, Balcerzyk-Matić, Anna, Iwanicka, Joanna, Iwanicki, Tomasz, Nowak, Tomasz, Szyluk, Karol, Kalita, Marcin, Górczyńska-Kosiorz, Sylwia, Kania, Wojciech, Niemiec, Paweł
Format: Article
Language:English
Subjects:
Adult
Alleles
Blood platelets
Chromosomes
Elbow
Female
Fibroblasts
Genes
Genotype
Genotype & phenotype
Growth factors
Haplotypes
Humans
Kinases
Male
Middle Aged
Patients
Platelet-Rich Plasma
Polymorphism
Polymorphism, Single Nucleotide
Prospective Studies
Receptor, Platelet-Derived Growth Factor alpha - genetics
Tendinopathy - genetics
Tendinopathy - therapy
Tennis Elbow - genetics
Tennis Elbow - therapy
Treatment Outcome
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container_issue 8
container_start_page 4266
container_title International journal of molecular sciences
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creator Jarosz, Alicja
Balcerzyk-Matić, Anna
Iwanicka, Joanna
Iwanicki, Tomasz
Nowak, Tomasz
Szyluk, Karol
Kalita, Marcin
Górczyńska-Kosiorz, Sylwia
Kania, Wojciech
Niemiec, Paweł
description Individual differences in the response to platelet-rich plasma (PRP) therapy can be observed among patients. The genetic background may be the cause of this variability. The current study focused on the impact of genetic variants on the effectiveness of PRP. The aim of the present study was to analyze the impact of single nucleotide polymorphisms (SNP) of the platelet-derived growth factor receptor alpha ( ) gene on the effectiveness of treating lateral elbow tendinopathy (LET) with PRP. The treatment's efficacy was analyzed over time (2, 4, 8, 12, 24, 52 and 104 weeks after the PRP injection) on 107 patients using patient-reported outcome measures (PROM) and achievement of a minimal clinically important difference (MCID). Four SNPs of the gene (rs7668190, rs6554164, rs869978 and rs1316926) were genotyped using the TaqMan assay method. Patients with the AA genotypes of the rs7668190 and the rs1316926 polymorphisms, as well as carriers of the T allele of rs6554164 showed greater effectiveness of PRP therapy than carriers of other genotypes. Moreover, the studied SNPs influenced the platelets' parameters both in whole blood and in PRP. These results showed that gene polymorphisms affect the effectiveness of PRP treatment. Genotyping the rs6554164 and the rs1316926 SNPs may be considered for use in individualized patient selection for PRP therapy.
doi_str_mv 10.3390/ijms25084266
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The genetic background may be the cause of this variability. The current study focused on the impact of genetic variants on the effectiveness of PRP. The aim of the present study was to analyze the impact of single nucleotide polymorphisms (SNP) of the platelet-derived growth factor receptor alpha ( ) gene on the effectiveness of treating lateral elbow tendinopathy (LET) with PRP. The treatment's efficacy was analyzed over time (2, 4, 8, 12, 24, 52 and 104 weeks after the PRP injection) on 107 patients using patient-reported outcome measures (PROM) and achievement of a minimal clinically important difference (MCID). Four SNPs of the gene (rs7668190, rs6554164, rs869978 and rs1316926) were genotyped using the TaqMan assay method. Patients with the AA genotypes of the rs7668190 and the rs1316926 polymorphisms, as well as carriers of the T allele of rs6554164 showed greater effectiveness of PRP therapy than carriers of other genotypes. 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subjects Adult
Alleles
Blood platelets
Chromosomes
Elbow
Female
Fibroblasts
Genes
Genotype
Genotype & phenotype
Growth factors
Haplotypes
Humans
Kinases
Male
Middle Aged
Patients
Platelet-Rich Plasma
Polymorphism
Polymorphism, Single Nucleotide
Prospective Studies
Receptor, Platelet-Derived Growth Factor alpha - genetics
Tendinopathy - genetics
Tendinopathy - therapy
Tennis Elbow - genetics
Tennis Elbow - therapy
Treatment Outcome
title Association between Platelet-Derived Growth Factor Receptor Alpha Gene Polymorphisms and Platelet-Rich Plasma's Efficiency in Treating Lateral Elbow Tendinopathy-A Prospective Cohort Study
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