Ligand-Free Iron-Catalyzed Construction of C–P Bonds via Phosphorylation of Alcohols: Synthesis of Phosphine Oxides and Phosphine Compounds

An efficient method for the construction of C–P­(V) and C–P­(III) bonds via the iron-catalyzed phosphorylation of alcohols under ligand-free conditions is disclosed. This strategy represents a straightforward process to prepare a series of phosphine oxides and phosphine compounds in good to excellen...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-05, Vol.89 (10), p.7047-7057
Main Authors: Gan, Liguang, Ye, Changxu, Pi, Tianshu, Wang, Lingling, Li, Chunya, Liu, Long, Huang, Tianzeng, Chen, Tieqiao, Han, Li-Biao
Format: Article
Language:English
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Summary:An efficient method for the construction of C–P­(V) and C–P­(III) bonds via the iron-catalyzed phosphorylation of alcohols under ligand-free conditions is disclosed. This strategy represents a straightforward process to prepare a series of phosphine oxides and phosphine compounds in good to excellent yields from the readily available alcohols and P–H compounds. A plausible mechanism is also proposed. We anticipate that this mode of transforming simple alcohols would apply in chemical synthesis widely.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.4c00439