Impact of COVID-19 on Pediatric Inflammatory Bowel Diseases-From Expectations to Reality

Viral infections have always been considered a threat to global health, with numerous outbreaks across time. Despite the relative recent experience with coronavirus-associated diseases such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), severe acute respirat...

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Bibliographic Details
Published in:Journal of personalized medicine 2024-04, Vol.14 (4), p.399
Main Authors: Trandafir, Laura Mihaela, Spoiala, Elena Lia, Ghiga, Gabriela, Gimiga, Nicoleta, Budescu, Paula-Diana, Lupu, Vasile Valeriu, Butnariu, Lacramioara, Cojocaru, Elena, Paduraru, Gabriela
Format: Article
Language:English
Subjects:
Adults
Bowel disease
Children
Chronic illnesses
Coronavirus infections
Coronaviruses
COVID-19
COVID-19 vaccines
Development and progression
Diseases
Dysbacteriosis
Evolution
Gastrointestinal diseases
Health care
Immune clearance
Immune system
Infection
Infection in children
Infections
Inflammation
Inflammatory bowel diseases
Intestine
Multisystem inflammatory syndrome in children
Pandemics
Pediatrics
Permeability
Public health
Respiratory diseases
Severe acute respiratory syndrome coronavirus 2
Steroids
Tropism
Viral antigens
Viral infections
World health
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Summary:Viral infections have always been considered a threat to global health, with numerous outbreaks across time. Despite the relative recent experience with coronavirus-associated diseases such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), severe acute respiratory syndrome-2's (SARS-CoV-2) continuous evolution displays a different behavior. With a tropism for both respiratory and digestive mucosa, coronavirus disease 2019 (COVID-19) and inflammatory bowel disease (IBD) seem to share a particular common background. Current literature offers evidence that viral alteration of the immune system, inflammatory intestinal tissue damage, increased intestinal permeability, incomplete viral clearance with viral antigen persistence, and intestinal dysbiosis, might explain SARS-CoV-2-IBD relationship in terms of etiopathogenesis and evolution. The hyperinflammatory state that both entities have in common explains the lack of success of current IBD therapy, raising the need for new personalized therapeutic options, with better outcomes for IBD and COVID-19 as well. This review aims to summarize the current available data on pediatric IBD evolution, management, and outcomes in the post-COVID period, with an emphasis on the particular aspects of the SARS-CoV-2-IBD relationship in children.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm14040399