Regulatory roles of microRNAs in modulating mitochondrial dynamics, amyloid beta fibrillation, microglial activation, and cholinergic signaling: Implications for alzheimer's disease pathogenesis

• Published in: Neuroscience and biobehavioral reviews 2024-06, Vol.161, p.105685-105685, Article 105685
• Main Authors: Sharma, Monika, Tanwar, Ankur Kumar, Purohit, Paresh Kumar, Pal, Pankaj, Kumar, Devendra, Vaidya, Sandeep, Prajapati, Santosh Kumar, Kumar, Aadesh, Dhama, Nidhi, Kumar, Sokindra, Gupta, Sukesh Kumar
• Format: Article
• Language: English
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Amyloid-beta pathology; Animals; Cholinergic signaling; Humans; Microglia - metabolism; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Mitochondrial Dynamics - physiology; Neuroinflammation; Signal Transduction - physiology
• ISSN: 0149-7634; 1873-7528
• DOI: 10.1016/j.neubiorev.2024.105685

Alzheimer's Disease (AD) remains a formidable challenge due to its complex pathology, notably involving mitochondrial dysfunction and dysregulated microRNA (miRNA) signaling. This study delves into the underexplored realm of miRNAs' impact on mitochondrial dynamics and their interplay with amyloid-beta (Aβ) aggregation and tau pathology in AD. Addressing identified gaps, our research utilizes advanced molecular techniques and AD models, alongside patient miRNA profiles, to uncover miRNAs pivotal in mitochondrial regulation. We illuminate novel miRNAs influencing mitochondrial dynamics, Aβ, and tau, offering insights into their mechanistic roles in AD progression. Our findings not only enhance understanding of AD's molecular underpinnings but also spotlight miRNAs as promising therapeutic targets. By elucidating miRNAs' roles in mitochondrial dysfunction and their interactions with hallmark AD pathologies, our work proposes innovative strategies for AD therapy, aiming to mitigate disease progression through targeted miRNA modulation. This contribution marks a significant step toward novel AD treatments, emphasizing the potential of miRNAs in addressing this complex disease. •miRNAs regulate key AD pathologies.•Aβ, tau impact on neuronal health.•Novel miRNA-based therapies explored.•Challenges in miRNA therapy delivery.•Future: personalized AD treatments.