Assessment of Clinical Outcomes in Patients With Osteoarthritis: Analysis From the UK Medical Cannabis Registry

Osteoarthritis accounts for 0.6% of disability-adjusted life years globally. There is a paucity of research focused on cannabis-based medicinal products (CBMPs) for osteoarthritic chronic pain management. This study aims to assess changes in validated patient-reported outcome measures (PROMs) and CB...

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Bibliographic Details
Published in:Journal of pain & palliative care pharmacotherapy 2024-06, Vol.38 (2), p.103-116
Main Authors: Francis, Ann, Erridge, Simon, Holvey, Carl, Coomber, Ross, Holden, Wendy, Rucker, James, Platt, Michael, Sodergren, Mikael
Format: Article
Language:English
Subjects:
Adult
Aged
Chronic Pain - drug therapy
Female
Humans
Male
Medical Marijuana - adverse effects
Medical Marijuana - therapeutic use
Middle Aged
Osteoarthritis - drug therapy
Pain Management - methods
Pain Measurement
Patient Reported Outcome Measures
Prospective Studies
Registries
Surveys and Questionnaires
Treatment Outcome
United Kingdom
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Summary:Osteoarthritis accounts for 0.6% of disability-adjusted life years globally. There is a paucity of research focused on cannabis-based medicinal products (CBMPs) for osteoarthritic chronic pain management. This study aims to assess changes in validated patient-reported outcome measures (PROMs) and CBMP clinical safety in patients with osteoarthritis. A prospective case series from the UK Medical Cannabis Registry was analyzed. Primary outcomes were changes in the Brief Pain Inventory (BPI), McGill Pain Questionnaire (MPQ2), EQ-5D-5L, Generalized Anxiety Disorder-7 (GAD-7) questionnaire, and Single-Item Sleep Quality Scale (SQS) at 1-, 3-, 6-, and 12-month follow-ups from baseline. Common Terminology Criteria for Adverse Events v.4.0 was used for adverse event (AE) analysis. Statistical significance was defined as  
ISSN:1536-0288
1536-0539
DOI:10.1080/15360288.2024.2340076