Invasive fungal disease in children with solid tumors: An Australian multicenter 10‐year review

Invasive fungal disease (IFD) occurs less frequently during treatment for solid compared to hematological malignancies in children, and risk groups are poorly defined. Retrospective national multicenter cohort data (2004–2013) were analyzed to document prevalence, clinical characteristics, and micro...

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Bibliographic Details
Published in:Pediatric blood & cancer 2024-07, Vol.71 (7), p.e31031-n/a
Main Authors: Jain, Neha, Ryan, Anne L., Haeusler, Gabrielle M., McMullan, Brendan J., Moore, Andrew S., Bartlett, Adam W., Blyth, Christopher C., Kotecha, Rishi S., Yeoh, Daniel K., Clark, Julia E.
Format: Article
Language:English
Subjects:
cancer
Children
Fungal diseases
invasive fungal disease
Malignancy
Neuroblastoma
prevalence
Prophylaxis
Risk groups
Solid tumors
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Summary:Invasive fungal disease (IFD) occurs less frequently during treatment for solid compared to hematological malignancies in children, and risk groups are poorly defined. Retrospective national multicenter cohort data (2004–2013) were analyzed to document prevalence, clinical characteristics, and microbiology of IFD. Amongst 2067 children treated for solid malignancy, IFD prevalence was 1.9% overall and 1.4% for proven/probable IFD. Of all IFD episodes, 42.5% occurred in patients with neuroblastoma (prevalence 7.0%). Candida species comprised 54.8% of implicated pathogens in proven/probable IFD. In children with solid tumors, IFD is rare, and predominantly caused by yeasts.Routine prophylaxis may not be warranted.
ISSN:1545-5009
1545-5017
1545-5017
DOI:10.1002/pbc.31031