Improving platelet function following prophylactic platelet transfusion in patients with hematological malignancies

Introduction Platelet transfusion is a standard treatment to prevent bleeding in patients with hematological malignancies. Although transfusions can improve platelet count, their impact on platelet function remains controversial. Methods We conducted flow cytometry to assess platelet function before...

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Published in:International journal of laboratory hematology 2024-08, Vol.46 (4), p.722-730
Main Authors: Wu, Yi‐Feng, Shen, Chih‐Lung, Huang, Wei‐Han, Chu, Sung‐Chao, Li, Chi‐Cheng, Liu, Chao‐Zong, Wang, Tso‐Fu
Format: Article
Language:English
Subjects:
Agonists
Apheresis
Blood groups
Blood levels
Blood platelets
Blood transfusion
Flow cytometry
Hematology
Malignancy
Microparticles
platelet
Platelets
Thrombin
thrombocytopenia
transfusion
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Summary:Introduction Platelet transfusion is a standard treatment to prevent bleeding in patients with hematological malignancies. Although transfusions can improve platelet count, their impact on platelet function remains controversial. Methods We conducted flow cytometry to assess platelet function before and after transfusion and performed subgroup analyses to examine differences based on blood type, corrected count increment (CCI), and platelet microparticles. Results Overall, 50 patients who received prophylactic platelet transfusion were enrolled. CD42b expression increased, whereas CD41 expression decreased after transfusion. Apheresis platelets exhibited the lowest expression of PAC‐1 and P‐selectin when exposed to agonist stimulations. PAC‐1 expression increased under high adenosine diphosphate (ADP) stimulation, while P‐selectin expression increased under both high ADP and thrombin receptor‐activating peptide stimulation. In the subgroup analysis, patients with a CCI >4500 and those with the same blood types exhibited a more significant increase in PAC‐1 and P‐selectin expression under agonist stimulation. When comparing apheresis platelets collected on different days, only the percentage of platelet‐derived microparticles showed a significant increase. Conclusion Prophylactic transfusion improved platelet function. Platelet function significantly improved in patients with a CCI >4500, those with the same blood types as that of apheresis platelets, or those with platelet‐derived microparticle levels
ISSN:1751-5521
1751-553X
1751-553X
DOI:10.1111/ijlh.14283