Injectable Testosterone PLGA Microsphere with Different Characteristics: Effect of Preparation Method (Paddle Mixing versus Microfluidic Device)

The purpose of this study was to compare the characteristics of testosterone polylactic-co-glycolic (PLGA) microspheres prepared by a paddle mixer or microfluidics device. The comparison was conducted by not only evaluation but also evaluation which has not been reported up to date. We discovered th...

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Bibliographic Details
Published in:Pharmaceutical development and technology 2024-05, Vol.29 (5), p.1-491
Main Authors: Oe, Yusuke, Kobayashi, Masanori, Yoshida, Takayuki, Kojima, Hiroyuki, Terukina, Takayuki, Kondo, Hiromu
Format: Article
Language:English
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Summary:The purpose of this study was to compare the characteristics of testosterone polylactic-co-glycolic (PLGA) microspheres prepared by a paddle mixer or microfluidics device. The comparison was conducted by not only evaluation but also evaluation which has not been reported up to date. We discovered that, among the steps in microsphere preparation, the solvent removal process strongly impacted drug content, particle size and surface morphology. Spectroscopic measurements suggested that molecular interactions and crystallinity of the drug incorporated in the microspheres differed. For the drug release profile, although both mixer- and microfluidics-prepared samples showed similar sustained release of the incorporated drug for approximately one month they exhibited different plasma concentration profiles . Together, our findings show that the preparation process, especially the solvent removal process, may affect the physicochemical characteristics of testosterone PLGA microspheres, leading to different performance.
ISSN:1083-7450
1097-9867
1097-9867
DOI:10.1080/10837450.2024.2348580