The relationship between serum levels of epidermal growth factor and β-human chorionic gonadotropin and the type and prognosis of ectopic pregnancy

• Published in: Archives of gynecology and obstetrics 2024-08, Vol.310 (2), p.1179-1187
• Main Authors: Geng, Dandan, Liu, Manfang, Wu, Dongyan, Yue, Benming
• Format: Article
• Language: English
• Subjects: Adult; Case-Control Studies; Chorionic Gonadotropin, beta Subunit, Human - blood; Endocrinology; Epidermal growth factor; Epidermal Growth Factor - blood; Female; General Gynecology; Gynecology; Human Genetics; Humans; Length of Stay - statistics & numerical data; Medicine; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Pregnancy; Pregnancy complications; Pregnancy Outcome; Pregnancy, Ectopic - blood; Pregnancy, Ectopic - diagnosis; Pregnancy, Tubal - blood; Pregnancy, Tubal - diagnosis; Prognosis
• ISSN: 1432-0711; 0932-0067; 1432-0711
• DOI: 10.1007/s00404-024-07523-0

Purpose This work aimed to explore the relationship between epidermal growth factor (EGF) and β-human chorionic gonadotropin (β-HCG) and ectopic pregnancy types and impact on prognosis. Methods Twenty women with normal pregnancies (NPs) were recruited as control group, and twenty women each with tubal pregnancy (TP) and cervical pregnancy (CP) were recruited. Blood samples were collected to detect EGF and β-HCG. Data on length of hospital stay and incidence of complications were collected. The differences in serum EGF and β-HCG levels were compared among groups and within various types of ectopic pregnancy using analysis of variance and Pearson correlation analysis. Results Serum EGF and β-HCG were notably lower in TP and CP group vs. controls ( P