Effect of pre-transplantation use of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in kidney transplant recipients—propensity score-matched analysis

• Published in: Journal of nephrology 2024-07, Vol.37 (6), p.1589-1597
• Main Authors: Lee, Jaeyun, Jung, Chan-Young, Kim, Hyosang, Kim, Hwa Jung, Ko, Youngmin, Kwon, Hyunwook, Shin, Sung, Kim, Young Hoon, Park, Su-Kil, Baek, Chung Hee
• Format: Article
• Language: English
• Subjects: Adult; Angiotensin Receptor Antagonists - adverse effects; Angiotensin Receptor Antagonists - therapeutic use; Angiotensin-Converting Enzyme Inhibitors - adverse effects; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Delayed Graft Function - etiology; Female; Graft Rejection - prevention & control; Graft Survival - drug effects; Humans; Hyperkalemia - chemically induced; Hyperkalemia - epidemiology; Kidney Transplantation; Male; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Original Article; Preoperative Care - methods; Propensity Score; Retrospective Studies; Urology
• ISSN: 1724-6059; 1724-6059
• DOI: 10.1007/s40620-024-01938-3

Background Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ACEi/ARBs) can cause acute kidney injury under dehydratation or in hemodynamically unstable conditions. Regarding kidney transplantation (KT), the risk of using ACEi/ARBs before surgery is not well established. Therefore, we evaluated the clinical outcomes to determine the effect of preoperative use of ACEi/ARBs on KT. Methods We retrospectively collected 1187 patients who received living-donor KT between January 2017 and December 2021. We conducted a propensity score-matched analysis between the ACEi/ARB(+) and ACEi/ARB(–) groups and evaluated the effects of ACEi/ARBs on delayed graft function, post-KT renal function, hyperkalemia events, rejection, and graft survival. Results The ACEi/ARB(+) group showed a similar incidence of delayed graft function as the ACEi/ARB(–) group (1.8% vs. 1.0%, P  = 0.362). The risk of delayed graft function was not upregulated in the ACEi/ARB(+) group after propensity score-matching (odds ratio: 0.50, 95% confidence interval (CI) 0.13–2.00). Postoperative creatinine levels and the slope of creatinine levels after KT also were not significantly different between the two groups (creatinine slope from POD#0 to POD#7: – 0.73 ± 0.35 vs. – 0.75 ± 0.32 mg/dL/day, P  = 0.464). Hyperkalemia did not occur more often in the ACEi/ARB(+) group than in the ACEi/ARB(–) group during perioperative days. Rejection-free survival ( P  = 0.920) and graft survival ( P  = 0.621) were not significantly different between the two groups. Conclusions In KT, the preoperative use of ACEi/ARBs did not significantly affect clinical outcomes including delayed graft function, postoperative renal function, hyperkalemia events, incidence of rejection, and graft survival rates compared to the patients who did not receive ACEi/ARBs. Graphical abstract