Free TcO 4- in 99m Tc-PSMA Scan : A Case Report and Review of an Old Pitfall in the New Era of Modern Imaging

In a recent 99m Tc-HYNIC-PSMA study conducted at our department, we examined 2 patients with prostate cancer referred for initial staging on the same day. The whole-body scans revealed radiotracer uptake in the gastric mucosa and thyroid glands, alluding to high levels of free TcO 4- in the injected...

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Bibliographic Details
Published in:Clinical nuclear medicine 2024-07, Vol.49 (7), p.e327-e328
Main Authors: Sahafi, Pegah, Aryana, Kamran, Moghadam, Soroush Zarehparvar, Sadri, Kayvan, Askari, Emran
Format: Article
Language:English
Subjects:
Aged
Antigens, Surface
Glutamate Carboxypeptidase II - metabolism
Humans
Male
Middle Aged
Organotechnetium Compounds
Prostatic Neoplasms - diagnostic imaging
Whole Body Imaging
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Summary:In a recent 99m Tc-HYNIC-PSMA study conducted at our department, we examined 2 patients with prostate cancer referred for initial staging on the same day. The whole-body scans revealed radiotracer uptake in the gastric mucosa and thyroid glands, alluding to high levels of free TcO 4- in the injected vial. The scans were repeated after confirming acceptable radiopharmaceutical purity of 97% (normal range, 95%-100%). Interestingly, 1 patient had liver metastases at presentation, which remained non-PSMA-avid after repeating the scan. We have reviewed this pitfall, which has been reported with many radiotracers, yet not reported with PSMA tracers.
ISSN:1536-0229
DOI:10.1097/RLU.0000000000005240