Dietary chamomile flowers extract improved performance and mitigated aflatoxin B1 toxicity in rabbits

• Published in: Journal of animal physiology and animal nutrition 2024-09, Vol.108 (5), p.1348-1359
• Main Authors: Rashad, Mahmoud Gamal, Arafa, Mahmoud Mohamed, El‐Zanaty, Abd Elfattah Ibrahim, El‐Saeed Lasheen, Mohamed, El‐Ashram, Saeed Abdelalim, Al‑Olayan, Ebtesam Mohamed, Hegazy, Mostafa Mahmoud, Farouk, Mohammed Hamdy
• Format: Article
• Language: English
• Subjects: Aflatoxin; Aflatoxin B1; Aflatoxin B1 - toxicity; Aflatoxins; Animal Feed - analysis; Animals; Antioxidants; chamomile; Chamomile - chemistry; Damage assessment; Diet - veterinary; Dietary Supplements; Enzymes; Flowers - chemistry; Food availability; Food contamination; Food poisoning; food security; Glutathione; Inflammation; Inflammatory response; Liver; Liver - drug effects; Male; Mycotoxins; Oxidative stress; Oxidative Stress - drug effects; Performance evaluation; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Rabbits; Superoxide dismutase; Toxicity
• ISSN: 0931-2439; 1439-0396; 1439-0396
• DOI: 10.1111/jpn.13974

Aflatoxin B1 (AFB1) is among the poisonous mycotoxins that contaminate food and feed. Limited studies are available on the efficacy of chamomile (Cha) against oxidative stress, liver damage and pro‐inflammatory response induced by AFB1. The present study aims to evaluate the effects of Cha on the performance and protective effects against AFB1 in growing rabbits. The experimental rabbits were divided into four different groups, including Cha (70 mg kg day−1), AFB1 (AF; 30 μg kg day−1), AFB1+Cha (AFLCha) and control (CON). The results indicated that the AFB1 treatment had lower values of performance, and carcass parameters compared to the Cha and AFLCha treatments. Furthermore, the Cha and AFLCha groups had lower values of liver and kidney function activities compared to the AFB1 treatment. The higher values of antioxidant enzymes were observed in Cha and AFLCha treatments than in the AFB1 treatment. AFB1 treatments had higher levels of malondialdehyde and liver functions with lower levels of antioxidant enzymes (glutathione and superoxide dismutase) compared to Cha and CON groups. In conclusion, dietary Cha could mitigate the oxidative stress of AFB1‐induced liver deterioration.