Reactive Plasmacytosis Immediately After Immunosuppressive Therapy With Anti-human Thymocyte Immunoglobulin for Severe Aplastic Anemia: A Report of a Rare Case

Aplastic anemia is a hematopoietic deficiency disorder with pancytopenia, and immunosuppressive therapy is effective. We report a case in which plasma cells appeared in the peripheral blood during immunosuppressive therapy for aplastic anemia. Based on the results of morphology and flow cytometry, t...

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Bibliographic Details
Published in:Cureus 2024, Vol.16 (3), p.e57255-e57255
Main Authors: Shimada, Tomohito, Bando, Kana, Takahata, Atsushi, Toyota, Shigeo
Format: Report
Language:English
Online Access:Get full text
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Summary:Aplastic anemia is a hematopoietic deficiency disorder with pancytopenia, and immunosuppressive therapy is effective. We report a case in which plasma cells appeared in the peripheral blood during immunosuppressive therapy for aplastic anemia. Based on the results of morphology and flow cytometry, the plasma cells were considered reactive and disappeared spontaneously after follow-up. Thereafter, the patient had a good hematopoietic recovery. Reactive plasmacytosis has been reported in infectious and autoimmune diseases, but this is the first report of reactive plasmacytosis during immunosuppressive therapy for aplastic anemia, to our knowledge. In this case, reactive plasmacytosis was a sign preceding good hematopoietic recovery.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.57255