Short-term dietary teprenone improved thermal tolerance and mitigated liver damage caused by heat stress in juvenile largemouth bass (Micropterus salmoides)

• Published in: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2024-08, Vol.273, p.110984-110984, Article 110984
• Main Authors: Li, Hongyun, Chen, Feifei, Qin, Mu, Liao, Chenlei, Shi, Yaqi, Wu, Sihan, Rong, Keming, Zhang, Xuezhen
• Format: Article
• Language: English
• Subjects: Heat shock proteins (HSPs); Heat stress; Laboratory experiment; Largemouth bass; Liver; Teprenone
• ISSN: 1096-4959; 1879-1107
• DOI: 10.1016/j.cbpb.2024.110984

Heat stress seriously threatens fish survival and health, demanding immediate attention. Teprenone is a gastric mucosal protective agent that can induce heat shock protein expression. This research investigated the effects of teprenone on largemouth bass (Micropterus salmoides) subjected to heat stress. Juvenile fish were assigned to different groups: group C (control group, 0 mg teprenone/kg diet), T0, T200, T400, and T800 (0, 200, 400, and 800 mg teprenone/kg diet, respectively), which were fed for 3 days, followed by a day without the diet. All groups except group C were subjected to acute heat stress (from 24 °C to 35 °C at 1 °C per hour and then maintained at 35 °C for 3 h). The results were as follows: The critical thermal maxima were significantly higher in the T200, T400, and T800 groups compared with the T0 group (P