The immunosuppressive landscape in tumor microenvironment

Recent advances in cancer immunotherapy, especially immune checkpoint inhibitors (ICIs), have revolutionized the clinical outcome of many cancer patients. Despite the fact that impressive progress has been made in recent decades, the response rate remains unsatisfactory, and many patients do not ben...

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Bibliographic Details
Published in:Immunologic research 2024-08, Vol.72 (4), p.566-582
Main Authors: Liu, Wuyi, Zhou, Huyue, Lai, Wenjing, Hu, Changpeng, Xu, Rufu, Gu, Peng, Luo, Menglin, Zhang, Rong, Li, Guobing
Format: Article
Language:English
Subjects:
Allergology
Antibodies
Antigen presentation
Biomedical and Life Sciences
Biomedicine
Cancer immunotherapy
Cancer therapies
Cell adhesion & migration
Clinical outcomes
Cytokines
Dendritic cells
Immune checkpoint inhibitors
Immune system
Immunity (Disease)
Immunoglobulins
Immunology
Immunosuppressive agents
Immunotherapy
Internal Medicine
Kinases
Leukemia
Leukocytes
Ligands
Lupus
Lymphocytes
Medicine/Public Health
Melanoma
Metabolism
Metabolites
Peptides
Proteins
Response rates
Review
Tumor microenvironment
Tumors
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Summary:Recent advances in cancer immunotherapy, especially immune checkpoint inhibitors (ICIs), have revolutionized the clinical outcome of many cancer patients. Despite the fact that impressive progress has been made in recent decades, the response rate remains unsatisfactory, and many patients do not benefit from ICIs. Herein, we summarized advanced studies and the latest insights on immune inhibitory factors in the tumor microenvironment. Our in-depth discussion and updated landscape of tumor immunosuppressive microenvironment may provide new strategies for reversing tumor immune evasion, enhancing the efficacy of ICIs therapy, and ultimately achieving a better clinical outcome.
ISSN:0257-277X
1559-0755
1559-0755
DOI:10.1007/s12026-024-09483-8