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The immunosuppressive landscape in tumor microenvironment
Recent advances in cancer immunotherapy, especially immune checkpoint inhibitors (ICIs), have revolutionized the clinical outcome of many cancer patients. Despite the fact that impressive progress has been made in recent decades, the response rate remains unsatisfactory, and many patients do not ben...
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| Published in: | Immunologic research 2024-08, Vol.72 (4), p.566-582 |
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| Main Authors: | , , , , , , , , |
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| container_end_page | 582 |
| container_issue | 4 |
| container_start_page | 566 |
| container_title | Immunologic research |
| container_volume | 72 |
| creator | Liu, Wuyi Zhou, Huyue Lai, Wenjing Hu, Changpeng Xu, Rufu Gu, Peng Luo, Menglin Zhang, Rong Li, Guobing |
| description | Recent advances in cancer immunotherapy, especially immune checkpoint inhibitors (ICIs), have revolutionized the clinical outcome of many cancer patients. Despite the fact that impressive progress has been made in recent decades, the response rate remains unsatisfactory, and many patients do not benefit from ICIs. Herein, we summarized advanced studies and the latest insights on immune inhibitory factors in the tumor microenvironment. Our in-depth discussion and updated landscape of tumor immunosuppressive microenvironment may provide new strategies for reversing tumor immune evasion, enhancing the efficacy of ICIs therapy, and ultimately achieving a better clinical outcome. |
| doi_str_mv | 10.1007/s12026-024-09483-8 |
| format | article |
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| subjects | Allergology Antibodies Antigen presentation Biomedical and Life Sciences Biomedicine Cancer immunotherapy Cancer therapies Cell adhesion & migration Clinical outcomes Cytokines Dendritic cells Immune checkpoint inhibitors Immune system Immunity (Disease) Immunoglobulins Immunology Immunosuppressive agents Immunotherapy Internal Medicine Kinases Leukemia Leukocytes Ligands Lupus Lymphocytes Medicine/Public Health Melanoma Metabolism Metabolites Peptides Proteins Response rates Review Tumor microenvironment Tumors |
| title | The immunosuppressive landscape in tumor microenvironment |
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