Specific and shared biological functions of PARP2 – is PARP2 really a lil’ brother of PARP1?

PARP2, that belongs to the family of ADP-ribosyl transferase enzymes (ART), is a discovery of the millennium, as it was identified in 1999. Although PARP2 was described initially as a DNA repair factor, it is now evident that PARP2 partakes in the regulation or execution of multiple biological proce...

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Bibliographic Details
Published in:Expert reviews in molecular medicine 2024-05, Vol.26, p.e13, Article e13
Main Authors: Szántó, Magdolna, Yélamos, José, Bai, Péter
Format: Article
Language:English
Subjects:
Amino acids
Animals
Carcinogenesis
Carcinogenesis - genetics
Carcinogenesis - metabolism
DNA Repair
Enzymes
Genes
Humans
Inflammation - metabolism
Liver cancer
Localization
Metabolism
MicroRNAs
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Oxidative metabolism
Oxidative Stress
Poly (ADP-Ribose) Polymerase-1 - metabolism
Poly(ADP-ribose) polymerase
Poly(ADP-ribose) Polymerases - genetics
Poly(ADP-ribose) Polymerases - metabolism
Proteins
Review
Thymus gland
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Summary:PARP2, that belongs to the family of ADP-ribosyl transferase enzymes (ART), is a discovery of the millennium, as it was identified in 1999. Although PARP2 was described initially as a DNA repair factor, it is now evident that PARP2 partakes in the regulation or execution of multiple biological processes as inflammation, carcinogenesis and cancer progression, metabolism or oxidative stress-related diseases. Hereby, we review the involvement of PARP2 in these processes with the aim of understanding which processes are specific for PARP2, but not for other members of the ART family. A better understanding of the specific functions of PARP2 in all of these biological processes is crucial for the development of new PARP-centred selective therapies.
ISSN:1462-3994
1462-3994
DOI:10.1017/erm.2024.14