Cross‐talk between leukemic and immune cells at the tumor microenvironment in chronic lymphocytic leukemia: An update review

Chronic lymphocytic leukemia (CLL) is a mature‐type B cell malignancy correlated with significant changes and defects in both the innate and adaptive arms of the immune system, together with a high dependency on the tumor microenvironment. Overall, the tumor microenvironment (TME) in CLL provides a...

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Bibliographic Details
Published in:European journal of haematology 2024-07, Vol.113 (1), p.4-15
Main Authors: Taghiloo, Saeid, Asgarian‐Omran, Hossein
Format: Article
Language:English
Subjects:
Animals
Cell Communication - immunology
Chronic lymphocytic leukemia
CLL
Disease resistance
Disease Susceptibility
Humans
Immune evasion
Immune system
Leukemia, Lymphocytic, Chronic, B-Cell - etiology
Leukemia, Lymphocytic, Chronic, B-Cell - immunology
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Malignancy
Tumor cells
Tumor Escape
Tumor microenvironment
Tumor Microenvironment - immunology
Tumors
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Description
Summary:Chronic lymphocytic leukemia (CLL) is a mature‐type B cell malignancy correlated with significant changes and defects in both the innate and adaptive arms of the immune system, together with a high dependency on the tumor microenvironment. Overall, the tumor microenvironment (TME) in CLL provides a supportive niche for leukemic cells to grow and survive, and interactions between CLL cells and the TME can contribute to disease progression and treatment resistance. Therefore, the increasing knowledge of the complicated interaction between immune cells and tumor cells, which is responsible for immune evasion and cancer progression, has provided an opportunity for the development of new therapeutic approaches. In this review, we outline tumor microenvironment‐driven contributions to the licensing of immune escape mechanisms in CLL patients.
ISSN:0902-4441
1600-0609
DOI:10.1111/ejh.14224