Probiotics enhance alveolar bone microarchitecture, intestinal morphology and estradiol levels in osteoporotic animals

Background and Objective Osteoporosis is associated with bone microarchitecture alterations, and the depletion of estrogen during menopause is a major contributing factor to its development. The literature highlights the noteworthy role of gut microbiota in bone metabolism, particularly in the progr...

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Published in:Journal of periodontal research 2024-08, Vol.59 (4), p.758-770
Main Authors: Lucateli, R. L., Silva, P. H. F., Salvador, S. L., Ervolino, E., Furlaneto, F. A. C., Marciano, M. A., Antunes, T. B. M., Del Arco, M. C. G., Tardelli, M. D. C., Sousa, L. G., Messora, M. R.
Format: Article
Language:English
Subjects:
17β-Estradiol
Alveolar bone
Animal models
Animals
Bifidobacterium animalis
Blood levels
Bone density
Bone loss
Bone turnover
Connective tissues
Epithelium
Estrogens
intestinal
Intestinal microflora
Intestine
Lacticaseibacillus casei
Leukocytes (neutrophilic)
Menopause
Microbiota
Osteoporosis
Ovariectomy
Periodontal diseases
Porosity
Probiotics
rats
Statistical analysis
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Summary:Background and Objective Osteoporosis is associated with bone microarchitecture alterations, and the depletion of estrogen during menopause is a major contributing factor to its development. The literature highlights the noteworthy role of gut microbiota in bone metabolism, particularly in the progression of osteoporosis. Periodontal disease leads to alveolar bone loss, which may be influenced by estrogen deficiency, and this mechanism is intricately associated with an imbalance in systemic microbiota. The aim of this study was to evaluate the effects of Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) and Lacticaseibacillus casei 01 (L. casei 01) administrations on an osteoporosis animal model. Materials and Methods Thirty‐three female rats were randomly divided into three groups: control (C‐OVX), C‐OVX‐HN019 and C‐OVX‐LC01. All animals were ovariectomized. In groups C‐OVX‐HN019 and C‐OVX‐LC01, the probiotics were administered for 4 months. All animals were euthanized after 16 weeks from ovariectomy. Microtomographic, histopathological and immunohistochemical examinations were conducted on periodontal tissues, whereas histomorphometry, histopathological and immunohistochemical analyses were carried out on the intestine. The levels of estradiol were assessed in blood using an immunoenzymatic assay. The data were subjected to statistical analyses (p 
ISSN:0022-3484
1600-0765
1600-0765
DOI:10.1111/jre.13256