Combination of cytoplasmic and nuclear patterns on Hep-2 antinuclear antibody is useful as a screening test for anti-synthetase syndrome

This study aimed to establish a screening model for differentiating anti-synthetase syndrome (ASS) from other ANA-associated rheumatic diseases (AARDs) using a combination of cytoplasmic and non-cytoplasmic ANA (ncANA) patterns. : This retrospective observational study included patients with AARDs s...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2024-09, Vol.63 (9), p.2590-2596
Main Authors: Yoshida, Katsuyuki, Takahashi, Soshi, Kawai, Ryota, Saito, Toshiharu, Hatachi, Saori, Shintani, Ayumi, Sugawara, Hitoshi, Kumagai, Shunichi
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies, Antinuclear - blood
Cell Nucleus - immunology
Cytoplasm - immunology
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Myositis - blood
Myositis - diagnosis
Myositis - immunology
Retrospective Studies
Rheumatic Diseases - diagnosis
Rheumatic Diseases - immunology
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Summary:This study aimed to establish a screening model for differentiating anti-synthetase syndrome (ASS) from other ANA-associated rheumatic diseases (AARDs) using a combination of cytoplasmic and non-cytoplasmic ANA (ncANA) patterns. : This retrospective observational study included patients with AARDs such as SLE, SSc, SS, MCTD and PM/DM who underwent ANA screening between April 2012 and December 2021. Variables included age, sex, ANA patterns (Cytoplasmic and ncANA) and titres. Logistic regression analysis of Cytoplasmic and ncANA patterns was performed to differentiate ASS from other AARDs. : The 981 diagnosed cases of AARDs consisted of SS (n = 451), SSc (n = 264), SLE (n = 201), PM/DM (n = 104), MCTD (n = 52) and ASS, including PM/DM (n = 64). Of these, 155 patients had ≥2 overlapping diseases; however, there was no overlap between AARDs and ASS. ASS is more likely to occur when the cytoplasmic titre is positive and the ncANA
ISSN:1462-0324
1462-0332
1462-0332
DOI:10.1093/rheumatology/keae245